• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

环境条件影响雪貂体内H3N2季节性流感病毒和变异流感病毒的呼出及呼吸道飞沫传播。

Environmental Conditions Affect Exhalation of H3N2 Seasonal and Variant Influenza Viruses and Respiratory Droplet Transmission in Ferrets.

作者信息

Gustin Kortney M, Belser Jessica A, Veguilla Vic, Zeng Hui, Katz Jacqueline M, Tumpey Terrence M, Maines Taronna R

机构信息

Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

出版信息

PLoS One. 2015 May 13;10(5):e0125874. doi: 10.1371/journal.pone.0125874. eCollection 2015.

DOI:10.1371/journal.pone.0125874
PMID:25969995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4430532/
Abstract

The seasonality of influenza virus infections in temperate climates and the role of environmental conditions like temperature and humidity in the transmission of influenza virus through the air are not well understood. Using ferrets housed at four different environmental conditions, we evaluated the respiratory droplet transmission of two influenza viruses (a seasonal H3N2 virus and an H3N2 variant virus, the etiologic virus of a swine to human summertime infection) and concurrently characterized the aerosol shedding profiles of infected animals. Comparisons were made among the different temperature and humidity conditions and between the two viruses to determine if the H3N2 variant virus exhibited enhanced capabilities that may have contributed to the infections occurring in the summer. We report here that although increased levels of H3N2 variant virus were found in ferret nasal wash and exhaled aerosol samples compared to the seasonal H3N2 virus, enhanced respiratory droplet transmission was not observed under any of the environmental settings. However, overall environmental conditions were shown to modulate the frequency of influenza virus transmission through the air. Transmission occurred most frequently at 23°C/30%RH, while the levels of infectious virus in aerosols exhaled by infected ferrets agree with these results. Improving our understanding of how environmental conditions affect influenza virus infectivity and transmission may reveal ways to better protect the public against influenza virus infections.

摘要

在温带气候中，流感病毒感染的季节性以及温度和湿度等环境条件在流感病毒空气传播中的作用尚未得到充分了解。我们使用饲养在四种不同环境条件下的雪貂，评估了两种流感病毒（一种季节性H3N2病毒和一种H3N2变异病毒，即猪到人夏季感染的病原病毒）的呼吸道飞沫传播情况，并同时对感染动物的气溶胶排放情况进行了表征。对不同温度和湿度条件以及两种病毒之间进行了比较，以确定H3N2变异病毒是否表现出可能导致夏季感染发生的增强能力。我们在此报告，尽管与季节性H3N2病毒相比，在雪貂鼻腔冲洗液和呼出的气溶胶样本中发现H3N2变异病毒的水平有所增加，但在任何环境设置下均未观察到增强的呼吸道飞沫传播。然而，总体环境条件显示出可调节流感病毒通过空气传播的频率。传播最常发生在23°C/30%相对湿度时，而感染雪貂呼出的气溶胶中传染性病毒的水平与这些结果一致。增进我们对环境条件如何影响流感病毒感染性和传播的理解，可能会揭示出更好地保护公众免受流感病毒感染的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/b3bfbeceb1c7/pone.0125874.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/16dbe2dfd83a/pone.0125874.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/521db8d1aecd/pone.0125874.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/4d04392a920d/pone.0125874.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/ba4cde389c48/pone.0125874.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/90b952226271/pone.0125874.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/da596ed9cbf3/pone.0125874.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/3cd7a744ac4d/pone.0125874.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/b3bfbeceb1c7/pone.0125874.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/16dbe2dfd83a/pone.0125874.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/521db8d1aecd/pone.0125874.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/4d04392a920d/pone.0125874.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/ba4cde389c48/pone.0125874.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/90b952226271/pone.0125874.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/da596ed9cbf3/pone.0125874.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/3cd7a744ac4d/pone.0125874.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ccf/4430532/b3bfbeceb1c7/pone.0125874.g008.jpg

相似文献

1
Environmental Conditions Affect Exhalation of H3N2 Seasonal and Variant Influenza Viruses and Respiratory Droplet Transmission in Ferrets.环境条件影响雪貂体内H3N2季节性流感病毒和变异流感病毒的呼出及呼吸道飞沫传播。
PLoS One. 2015 May 13;10(5):e0125874. doi: 10.1371/journal.pone.0125874. eCollection 2015.
2
Pathogenesis and Transmission of Genetically Diverse Swine-Origin H3N2 Variant Influenza A Viruses from Multiple Lineages Isolated in the United States, 2011-2016.2011-2016 年美国分离的多种谱系遗传多样化猪源 H3N2 变异流感 A 病毒的发病机制和传播。
J Virol. 2018 Jul 31;92(16). doi: 10.1128/JVI.00665-18. Print 2018 Aug 15.
3
Impact of prior seasonal H3N2 influenza vaccination or infection on protection and transmission of emerging variants of influenza A(H3N2)v virus in ferrets.季节性 H3N2 流感疫苗接种或感染对雪貂中新型甲型流感病毒（H3N2）v 变体的保护和传播的影响。
J Virol. 2013 Dec;87(24):13480-9. doi: 10.1128/JVI.02434-13. Epub 2013 Oct 2.
4
Aerosol Transmission from Infected Swine to Ferrets of an H3N2 Virus Collected from an Agricultural Fair and Associated with Human Variant Infections.从农业展览会上收集的与人类变异感染相关的 H3N2 病毒感染猪向雪貂的气溶胶传播。
J Virol. 2020 Jul 30;94(16). doi: 10.1128/JVI.01009-20.
5
Seasonal influenza viruses decay more rapidly at intermediate humidity in droplets containing saliva compared to respiratory mucus.与呼吸道黏液相比，含唾液的飞沫中的季节性流感病毒在中等湿度下更快衰减。
Appl Environ Microbiol. 2024 Feb 21;90(2):e0201023. doi: 10.1128/aem.02010-23. Epub 2024 Jan 9.
6
Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo.雪貂之间缺乏具有禽受体特异性的人流感病毒传播并非由于病毒脱落减少，而是体内感染性降低所致。
J Gen Virol. 2011 Aug;92(Pt 8):1822-1831. doi: 10.1099/vir.0.031203-0. Epub 2011 Apr 20.
7
Swine-Origin H1 Influenza Viruses Isolated from Humans Exhibit Sustained Infectivity in an Aerosol State.从人类中分离出的猪源 H1 流感病毒在气溶胶状态下具有持续的感染性。
Appl Environ Microbiol. 2019 May 2;85(10). doi: 10.1128/AEM.00210-19. Print 2019 May 15.
8
Environmental Persistence of Influenza Viruses Is Dependent upon Virus Type and Host Origin.流感病毒的环境持久性取决于病毒类型和宿主来源。
mSphere. 2019 Aug 21;4(4):e00552-19. doi: 10.1128/mSphere.00552-19.
9
Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets.猪源 A(H3N2)v 流感病毒在雪貂中的发病机制和传播。
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3944-9. doi: 10.1073/pnas.1119945109. Epub 2012 Feb 21.
10
Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain.2009 年流感大流行病毒的传播对温度和湿度的敏感性与 H3N2 季节性流感株相似。
J Virol. 2011 Feb;85(3):1400-2. doi: 10.1128/JVI.02186-10. Epub 2010 Nov 17.

引用本文的文献

1
Impact of airflow stimulation: mild cold airflow is more sensitive to influenza virus infection.气流刺激的影响：轻度冷气流对流感病毒感染更为敏感。
J Thorac Dis. 2025 Jun 30;17(6):3643-3657. doi: 10.21037/jtd-24-1546. Epub 2025 Jun 23.
2
Bioaerosols and Airborne Transmission in the Dental Clinic.口腔诊室中的生物气溶胶与空气传播
Int Dent J. 2024 Nov;74 Suppl 2(Suppl 2):S418-S428. doi: 10.1016/j.identj.2024.09.026.
3
Dependence of aerosol-borne influenza A virus infectivity on relative humidity and aerosol composition.气溶胶传播的甲型流感病毒传染性对相对湿度和气溶胶成分的依赖性。

本文引用的文献

1
Update: influenza activity -- United States and worldwide, May 18-September 20, 2014.更新：2014年5月18日至9月20日美国及全球流感活动情况
MMWR Morb Mortal Wkly Rep. 2014 Oct 3;63(39):861-4.
2
Animal models for influenza virus pathogenesis, transmission, and immunology.流感病毒发病机制、传播和免疫学的动物模型。
J Immunol Methods. 2014 Aug;410:60-79. doi: 10.1016/j.jim.2014.03.023. Epub 2014 Apr 4.
3
Impact of prior seasonal H3N2 influenza vaccination or infection on protection and transmission of emerging variants of influenza A(H3N2)v virus in ferrets.
Front Microbiol. 2024 Oct 16;15:1484992. doi: 10.3389/fmicb.2024.1484992. eCollection 2024.
4
Laboratory studies on the infectivity of human respiratory viruses: Experimental conditions, detections, and resistance to the atmospheric environment.人类呼吸道病毒传染性的实验室研究：实验条件、检测及对大气环境的抵抗力
Fundam Res. 2024 Feb 21;4(3):471-483. doi: 10.1016/j.fmre.2023.12.017. eCollection 2024 May.
5
Dependence on relative humidity in the formation of reactive oxygen species in water droplets.水滴中活性氧形成对相对湿度的依赖性。
Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2315940121. doi: 10.1073/pnas.2315940121. Epub 2024 Mar 15.
6
Viral respiratory infections in a rapidly changing climate: the need to prepare for the next pandemic.在快速变化的气候中应对病毒性呼吸道感染：为下一次大流行做好准备的必要性。
EBioMedicine. 2023 Jul;93:104593. doi: 10.1016/j.ebiom.2023.104593. Epub 2023 May 9.
7
Influenza A virus hemagglutinin prevents extensive membrane damage upon dehydration.甲型流感病毒血凝素可防止脱水时广泛的膜损伤。
BBA Adv. 2022 Mar 5;2:100048. doi: 10.1016/j.bbadva.2022.100048. eCollection 2022.
8
Aerosolize this: Generation, collection, and analysis of aerosolized virus in laboratory settings.将此进行雾化处理：实验室环境中雾化病毒的产生、收集与分析。
PLoS Pathog. 2023 Mar 9;19(3):e1011178. doi: 10.1371/journal.ppat.1011178. eCollection 2023 Mar.
9
Associations between indoor relative humidity and global COVID-19 outcomes.室内相对湿度与全球 COVID-19 结局的关联。
J R Soc Interface. 2022 Nov;19(196):20210865. doi: 10.1098/rsif.2021.0865. Epub 2022 Nov 16.
10
The impact of heating, ventilation and air conditioning (HVAC) design features on the transmission of viruses, including the 2019 novel coronavirus (COVID-19): A systematic review of humidity.加热、通风和空调（HVAC）设计特点对病毒传播的影响，包括 2019 年新型冠状病毒（COVID-19）：湿度的系统评价。
PLoS One. 2022 Oct 10;17(10):e0275654. doi: 10.1371/journal.pone.0275654. eCollection 2022.
季节性 H3N2 流感疫苗接种或感染对雪貂中新型甲型流感病毒（H3N2）v 变体的保护和传播的影响。
J Virol. 2013 Dec;87(24):13480-9. doi: 10.1128/JVI.02434-13. Epub 2013 Oct 2.
4
Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions.不同环境条件下中东呼吸综合征冠状病毒（MERS-CoV）的稳定性。
Euro Surveill. 2013 Sep 19;18(38):20590. doi: 10.2807/1560-7917.es2013.18.38.20590.
5
Outbreak of variant influenza A(H3N2) virus in the United States.美国爆发变异型甲型 H3N2 流感病毒。
Clin Infect Dis. 2013 Dec;57(12):1703-12. doi: 10.1093/cid/cit649. Epub 2013 Sep 24.
6
Comparison of the levels of infectious virus in respirable aerosols exhaled by ferrets infected with influenza viruses exhibiting diverse transmissibility phenotypes.比较具有不同传播表型的流感病毒感染雪貂呼出的可吸入气溶胶中的感染性病毒水平。
J Virol. 2013 Jul;87(14):7864-73. doi: 10.1128/JVI.00719-13. Epub 2013 May 8.
7
Influenza virus aerosols in human exhaled breath: particle size, culturability, and effect of surgical masks.人呼出的飞沫中的流感病毒：颗粒大小、可培养性和手术口罩的效果。
PLoS Pathog. 2013 Mar;9(3):e1003205. doi: 10.1371/journal.ppat.1003205. Epub 2013 Mar 7.
8
Environmental predictors of seasonal influenza epidemics across temperate and tropical climates.环境因素对温带和热带气候季节性流感流行的预测。
PLoS Pathog. 2013 Mar;9(3):e1003194. doi: 10.1371/journal.ppat.1003194. Epub 2013 Mar 7.
9
High humidity leads to loss of infectious influenza virus from simulated coughs.高湿度导致模拟咳嗽中传染性流感病毒的丧失。
PLoS One. 2013;8(2):e57485. doi: 10.1371/journal.pone.0057485. Epub 2013 Feb 27.
10
Relationship between humidity and influenza A viability in droplets and implications for influenza's seasonality.湿度与飞沫中甲型流感病毒存活能力的关系及其对流感季节性的影响。
PLoS One. 2012;7(10):e46789. doi: 10.1371/journal.pone.0046789. Epub 2012 Oct 3.