Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.
J Virol. 2011 Feb;85(3):1400-2. doi: 10.1128/JVI.02186-10. Epub 2010 Nov 17.
In temperate regions of the world, influenza epidemics follow a highly regular seasonal pattern, in which activity peaks in midwinter. Consistently with this epidemiology, we have shown previously that the aerosol transmission of a seasonal H3N2 influenza virus is most efficient under cold, dry conditions. With the 2009 H1N1 pandemic, an exception to the standard seasonality of influenza developed: during 2009 in the Northern Hemisphere, an unusually high level of influenza virus activity over the spring and summer months was followed by a widespread epidemic which peaked in late October, approximately 2.5 months earlier than usual. Herein we show that aerosol transmission of a 2009 pandemic strain shows a dependence on relative humidity and temperature very similar to that of a seasonal H3N2 influenza virus. Our data indicate that the observed differences in the timings of outbreaks with regard to the seasons are most likely not due to intrinsic differences in transmission between the pandemic H1N1 and seasonal H3N2 influenza viruses.
在世界温带地区，流感疫情呈现出高度规律的季节性模式，其活动高峰期在隆冬。与这种流行病学一致，我们之前已经表明，季节性 H3N2 流感病毒的气溶胶传播在寒冷、干燥的条件下效率最高。然而，2009 年 H1N1 大流行出现了一个例外：在 2009 年北半球，春季和夏季出现了异常高的流感病毒活动水平，随后出现了广泛的疫情，其高峰期在 10 月底，比往常提前了大约 2.5 个月。在此，我们表明，2009 年大流行株的气溶胶传播与季节性 H3N2 流感病毒非常相似，依赖于相对湿度和温度。我们的数据表明，大流行 H1N1 和季节性 H3N2 流感病毒之间在爆发时间上的差异最不可能是由于传播的内在差异造成的。
