CD38/HLA-DR CD8 T细胞作为内脏利什曼原虫感染继发噬血细胞性淋巴组织细胞增生症的潜在生物标志物。
CD38/HLA-DR CD8 T cells as potential biomarker of hemophagocytic lymphohistiocytosis secondary to visceral Leishmania infection.
作者信息
Mastrolia Maria Vincenza, Boscia Silvia, Galli Luisa, Lodi Lorenzo, Pisano Laura, Maccora Ilaria, Ricci Silvia, Pagnini Ilaria, Marrani Edoardo, Azzari Chiara, Simonini Gabriele
机构信息
Rheumatology Unit, Meyer Children's University Hospital, Viale Gaetano Pieraccini 24, Florence, 50139, Italy.
Immunology and Molecular Microbiology Unit, Meyer Children's University Hospital, Florence, Italy.
出版信息
Eur J Pediatr. 2023 Mar;182(3):1429-1432. doi: 10.1007/s00431-022-04789-x. Epub 2023 Jan 12.
UNLABELLED
Leishmaniasis is a cause of infection associated with hemophagocytic lymphohistiocytosis (HLH). The measurement of the CD8 CD38/HLA-DR T cells in children presenting with acute onset of shock and multisystem organ failure represents an important parameter to distinguish HLH from sepsis or healthy control.
CONCLUSION
We report a case series of 4 Italian children suffering from HLH secondary to visceral Leishmaniasis in which the lymphocyte subset assay suggests a potential role of CD38/HLA-DR CD8 T cells as HLH diagnostic biomarkers.
WHAT IS KNOWN
• Visceral Leishmaniasis is a well-known cause of infection associated with hemophagocytic lymphohistiocytosis (HLH). • The measurement of the CD8 CD38/HLA-DR T cells in children presenting with acute onset of shock and multisystem organ failure represents an important diagnostically useful parameter to readily distinguish HLH from sepsis or healthy controls.
WHAT IS NEW
• We report a case series of 4 Italian children suffering from HLH secondary to visceral Leishmaniasis in which the lymphocyte subset assay suggests a potential role of CD38/HLA-DR CD8 T cells as HLH diagnostic biomarker. • The flow cytometry assay, performed at the disease onset before starting treatment, revealed a mean percentage value of CD38 cells of 36.95% among CD8 T cells.
未标注
利什曼病是一种与噬血细胞性淋巴组织细胞增生症（HLH）相关的感染病因。对于出现急性休克和多系统器官衰竭的儿童，检测CD8 CD38/HLA-DR T细胞是区分HLH与败血症或健康对照的重要参数。
结论
我们报告了一组4例继发于内脏利什曼病的HLH意大利儿童病例系列，其中淋巴细胞亚群分析提示CD38/HLA-DR CD8 T细胞作为HLH诊断生物标志物的潜在作用。
已知信息
• 内脏利什曼病是一种与噬血细胞性淋巴组织细胞增生症（HLH）相关的已知感染病因。• 对于出现急性休克和多系统器官衰竭的儿童，检测CD8 CD38/HLA-DR T细胞是一个重要的诊断有用参数，可轻松区分HLH与败血症或健康对照。
新发现
• 我们报告了一组4例继发于内脏利什曼病的HLH意大利儿童病例系列，其中淋巴细胞亚群分析提示CD38/HLA-DR CD8 T细胞作为HLH诊断生物标志物的潜在作用。• 在开始治疗前疾病发作时进行的流式细胞术检测显示，CD8 T细胞中CD38细胞的平均百分比值为36.95%。
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