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[非结核分枝杆菌——关于流行病学、诊断与治疗的简要综述]

[Non Tuberculous Mycobacteria--a Short Review about Epidemiology, Diagnosis and Treatment].

作者信息

Bös L, Schönfeld N, Schaberg T

机构信息

Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose (DZK e.V.), Auf dem Gelände des Helios Klinikums Emil von Behring, Berlin.

Klinik für Pneumologie der Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring, Berlin.

出版信息

Pneumologie. 2015 May;69(5):287-93; quiz 294. doi: 10.1055/s-0034-1391971. Epub 2015 May 13.

Abstract

Non tuberculous mycobacterial diseases are caused by mycobacteria other than M. tuberculosis complex. NTM are found in the environment and are not transmitted from humans to humans. Infection occurs by the inhalation of dust or aerosols. The finding of NTM is not equal to a diagnosis of active disease. For the diagnosis of active disease well defined clinical and microbiological criteria have to be fulfilled. Gold standard is the detection of NTM by culture, in the case of pulmonary NTM at least two times. There is no established susceptibility testing. Treatment mostly consists of three drugs, given for up to 24 months.

摘要

非结核分枝杆菌病由结核分枝杆菌复合群以外的分枝杆菌引起。非结核分枝杆菌存在于环境中,不会在人与人之间传播。感染是通过吸入灰尘或气溶胶发生的。发现非结核分枝杆菌并不等同于诊断为活动性疾病。对于活动性疾病的诊断,必须满足明确的临床和微生物学标准。金标准是通过培养检测到非结核分枝杆菌,对于肺部非结核分枝杆菌感染,至少检测两次。目前尚无既定的药敏试验。治疗大多由三种药物组成,给药时间长达24个月。

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