轻度体力活动与结直肠癌后的生活质量相关。
Light Physical Activity Is Associated with Quality of Life after Colorectal Cancer.
作者信息
Van Roekel Eline H, Bours Martijn J L, Breedveld-Peters José J L, Meijer Kenneth, Kant Ijmert, Van Den Brandt Piet A, Sanduleanu Silvia, Beets Geerard L, Weijenberg Matty P
机构信息
1Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, THE NETHERLANDS; 2Department of Human Movement Science, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, THE NETHERLANDS; 3Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, THE NETHERLANDS; 4Department of Internal Medicine, Division of Gastroenterology and Hepatology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, THE NETHERLANDS; 5Department of Surgery, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, THE NETHERLANDS.
出版信息
Med Sci Sports Exerc. 2015 Dec;47(12):2493-503. doi: 10.1249/MSS.0000000000000698.
PURPOSE
Emerging evidence suggests that light physical activity (LPA), besides moderate-to-vigorous physical activity (MVPA), may beneficially influence physical functioning of colorectal cancer survivors, but its relation with other health-related outcomes is unknown. We applied a biopsychosocial approach to investigate independent associations between self-reported LPA, MVPA, and multiple health-related quality of life (HRQoL) outcomes in 2- to 10-yr postdiagnosis colorectal cancer survivors.
METHODS
Stage I-III colorectal cancer survivors diagnosed between 2002 and 2010 at Maastricht University Medical Center+, the Netherlands, were included in a cross-sectional study (n = 151). Time spent in LPA and MVPA (h·wk⁻¹), and HRQoL outcome scores (0-100 points) were assessed by validated questionnaires.
RESULTS
Median time spent in LPA and MVPA was 10.0 (interquartile range, 2.0-22.0) and 8.7 h·wk⁻¹ (4.5-15.0), respectively. In multivariable linear regression models, both LPA and MVPA were significantly and independently associated with higher physical functioning (mean difference [MD] between highest and lowest quartile, 10.2; 95% confidence interval [CI], 0.2-20.3; and 14.5; 5.1-23.9, respectively; both P-trend < 0.05). In addition, LPA was significantly associated with higher role functioning (MD, 19.5; 95% CI, 6.9-32.1; P-trend < 0.01) and lower disability (MD, -9.9; 95% CI, -17.8 to -1.9; P-trend = 0.02), independent from MVPA. Subgroup analyses showed that beneficial associations between LPA and HRQoL were mainly observed in women and participants with multiple comorbidities.
CONCLUSIONS
Self-reported LPA, besides MVPA, was beneficially associated with multiple HRQoL outcomes in colorectal cancer survivors, especially in women and survivors with multiple comorbidities. Prospective studies are warranted to establish whether LPA is a suitable target for personalized lifestyle interventions to improve the HRQoL of colorectal cancer survivors.
目的
新出现的证据表明，除了中度至剧烈身体活动（MVPA）外，轻度身体活动（LPA）可能对结直肠癌幸存者的身体机能产生有益影响，但其与其他健康相关结局的关系尚不清楚。我们采用生物心理社会方法，调查了确诊后2至10年的结直肠癌幸存者自我报告的LPA、MVPA与多种健康相关生活质量（HRQoL）结局之间的独立关联。
方法
纳入2002年至2010年期间在荷兰马斯特里赫特大学医学中心+确诊的I-III期结直肠癌幸存者进行横断面研究（n = 151）。通过经过验证的问卷评估LPA和MVPA的时间（小时·周⁻¹）以及HRQoL结局评分（0-100分）。
结果
LPA和MVPA的中位时间分别为10.0（四分位间距，2.0-22.0）和8.7小时·周⁻¹（4.5-15.0）。在多变量线性回归模型中，LPA和MVPA均与更高的身体机能显著且独立相关（最高和最低四分位数之间的平均差异[MD]分别为10.2；95%置信区间[CI]，0.2-20.3；以及14.5；5.1-23.9；两者P趋势<0.05）。此外，独立于MVPA，LPA与更高的角色功能（MD，19.5；95%CI，6.9-32.1；P趋势<0.01）和更低的残疾程度（MD，-9.9；95%CI，-17.8至-1.9；P趋势=0.02）显著相关。亚组分析表明，LPA与HRQoL之间的有益关联主要在女性和患有多种合并症的参与者中观察到。
结论
自我报告的LPA，除MVPA外，与结直肠癌幸存者的多种HRQoL结局有益相关，尤其是在女性和患有多种合并症的幸存者中。有必要进行前瞻性研究，以确定LPA是否是改善结直肠癌幸存者HRQoL的个性化生活方式干预的合适目标。
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