Research Center, Asahi Glass Co., Ltd., 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, Japan.
J Am Chem Soc. 2015 Jun 10;137(22):7031-4. doi: 10.1021/jacs.5b03342. Epub 2015 May 27.
This Communication describes a successful olefin cross-metathesis with tetrafluoroethylene and its analogues. A key to the efficient catalytic cycle is interconversion between two thermodynamically stable, generally considered sluggish, Fischer carbenes. This newly demonstrated catalytic transformation enables easy and short-step synthesis of a new class of partially fluorinated olefins bearing plural fluorine atoms, which are particularly important and valuable compounds in organic synthesis and medicinal chemistry as well as the materials and polymer industries.
本通讯描述了四氟乙烯及其类似物与烯烃的成功交叉复分解反应。高效催化循环的关键在于两种热力学稳定的、通常认为反应缓慢的费歇尔碳之间的相互转化。这种新展示的催化转化使含有多个氟原子的一类新型部分氟化烯烃的简便、短步骤合成成为可能，这些化合物在有机合成、药物化学以及材料和聚合物工业中都是特别重要和有价值的化合物。
