Tucker M J, Leung C K, Leong M K, Marriott V M, Chan Y M, Wong C J, Chan H H
Asia Oceania J Obstet Gynaecol. 1989 Sep;15(3):245-51. doi: 10.1111/j.1447-0756.1989.tb00184.x.
Gamete intrafallopian transfer (GIFT) is increasingly accepted as a realistic alternative to in vitro fertilization (IVF), or intrauterine insemination (IUI) for treatment of non-tubal infertility. The lack of information on fertilization capacity of the gametes, the greater cost relative to IUI, and the partly unsubstantiated claims of higher success rates, caused us some concern with the readiness with which GIFT had been accepted as a standard infertility treatment. So we undertook a provisional GIFT programme with these considerations in mind, and we report on the first 91 GIFT cycles performed in our clinic. Sixty of the patients (62 cycles) treated suffered from idiopathic infertility, 12 from minimal endometriosis, 9 from male factor infertility, and 8 from ovulatory dysfunction. An initial clinical pregnancy rate of 41% (38/91) was achieved; pregnancy loss was 23% (9/38), giving a continuing pregnancy rate of 32% (29/91). Given this undeniably encouraging result, and the potential for diagnostic IVF, embryo freezing, and ovum donation with surplus oocytes collected from this GIFT programme, we now have adopted GIFT permanently as a treatment to complement our IVF and IUI programmes.
配子输卵管内移植（GIFT）作为体外受精（IVF）或宫腔内人工授精（IUI）治疗非输卵管性不孕的一种切实可行的替代方法，越来越被人们所接受。由于缺乏关于配子受精能力的信息，相对于IUI成本更高，以及部分未经证实的更高成功率的说法，我们对GIFT被轻易接受为标准不孕治疗方法感到有些担忧。因此，我们在考虑这些因素的情况下开展了一项临时性的GIFT计划，并报告了我们诊所进行的前91个GIFT周期的情况。接受治疗的患者中有60例（62个周期）患有特发性不孕，12例患有轻度子宫内膜异位症，9例患有男性因素不孕，8例患有排卵功能障碍。初始临床妊娠率为41%（38/91）；妊娠丢失率为23%（9/38），持续妊娠率为32%（29/91）。鉴于这一不可否认的令人鼓舞的结果，以及利用从该GIFT计划中收集的多余卵母细胞进行诊断性IVF、胚胎冷冻和卵子捐赠的可能性，我们现在已永久采用GIFT作为一种治疗方法，以补充我们的IVF和IUI计划。
