Gati W P, Dagnino L, Paterson A R
Department of Pharmacology, University of Alberta, Edmonton, Canada.
Biochem J. 1989 Nov 1;263(3):957-60. doi: 10.1042/bj2630957.
In mediating the entry of adenosine into mouse erythrocytes and mouse leukaemia L1210 cells, nucleoside transport systems were stereoselective, showing a marked preference for the D-enantiomer of adenosine (D-Ado). Inward zero-trans fluxes of the mirror-image isomer, L-adenosine (L-Ado), in those cells were slow relative to those of D-Ado. Contributing to L-Ado fluxes in both cell types were (i) a transporter-mediated process of high nitrobenzylthioinosine-sensitivity and (ii) simple diffusion.
在介导腺苷进入小鼠红细胞和小鼠白血病L1210细胞的过程中，核苷转运系统具有立体选择性，对腺苷的D-对映体（D-Ado）表现出明显的偏好。在这些细胞中，镜像异构体L-腺苷（L-Ado）的内向零转运通量相对于D-Ado较慢。在这两种细胞类型中，L-Ado通量的贡献因素包括：（i）一种对硝基苄硫基肌苷高度敏感的转运体介导过程，以及（ii）简单扩散。
