Liu Peilian, Xu Jiangsheng, Yan Donghang, Zhang Peisheng, Zeng Fang, Li Bowen, Wu Shuizhu
College of Materials Science & Engineering, State Key Lab of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, P. R. China.
Chem Commun (Camb). 2015 Jun 11;51(46):9567-70. doi: 10.1039/c5cc02149a.
A DT-diaphorase-activatable theranostic prodrug, which contains camptothecin, a self-immolative linker and a trigger group, has been developed for the detection of DT-diaphorase, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase. This strategy may offer a new approach for the development of enzyme-catalyzed theranostic anticancer therapeutics.
一种可被DT-黄递酶激活的诊疗前药已被研发出来，它含有喜树碱、一个自毁连接子和一个触发基团，用于检测DT-黄递酶、追踪药物释放以及选择性杀死过度表达DT-黄递酶的癌细胞。该策略可能为酶催化的诊疗抗癌疗法的开发提供一种新方法。
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