State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.
University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
ACS Appl Mater Interfaces. 2021 Dec 22;13(50):59708-59719. doi: 10.1021/acsami.1c19058. Epub 2021 Dec 8.
Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess the NQO1-switched drug release and fluorescence enablement, which realizes the tumor-specific chemotherapy and imaging in living mice. The enzyme-sensitive prodrug nanoparticles exhibit selectively potent anticancer performance to NQO1-positive cancer and ignorable off-target toxicity. This work provides an alternative strategy for constructing smart prodrug nanoplatforms with precision, selectivity, and practicability for advanced cancer imaging and therapy.
响应性药物递送系统在疾病诊断和治疗方面具有巨大的潜力。在此，我们通过工程内源性 NAD(P)H：醌氧化还原酶-1（NQO1）响应性连接子，开发了一种可激活的前药和荧光成像材料。所制备的纳米材料具有 NQO1 开关的药物释放和荧光激活功能，可实现活体内小鼠的肿瘤特异性化学疗法和成像。酶敏感的前药纳米颗粒对 NQO1 阳性癌症表现出选择性的强大抗癌性能，而对非靶标毒性则可忽略不计。这项工作为构建具有精确性、选择性和实用性的智能前药纳米平台提供了一种替代策略，用于先进的癌症成像和治疗。
