Maliszewski-Hall Anne M, Alexander Michelle, Tkáč Ivan, Öz Gülin, Rao Raghavendra
Division of Neonatology, Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Suite 13-227, MMC 391, Minneapolis, MN, 55455, USA.
Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Neurochem Res. 2017 Jan;42(1):133-140. doi: 10.1007/s11064-015-1609-y. Epub 2015 May 14.
Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo H magnetic resonance (MR) spectroscopy at 9.4 T. IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague-Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N = 12) and NG (N = 13) rats. In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P < 0.01) and [glutamate]/[glutamine] ratio (P < 0.05). Lower taurine concentrations were observed in the hippocampus (P < 0.01) and striatum (P < 0.05). IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.
宫内生长受限（IUGR）婴儿出现神经发育缺陷的风险增加，这表明海马体和大脑皮层可能特别脆弱。使用9.4T的体内氢磁共振（MR）波谱评估IUGR和正常生长（NG）的7日龄大鼠幼崽的区域神经化学特征。在妊娠第19天，通过双侧子宫动脉结扎诱导怀孕的Sprague-Dawley母鼠发生IUGR。在P7时，从IUGR（N = 12）和NG（N = 13）大鼠的大脑皮层、海马体和纹状体获得MR波谱。在皮层中，IUGR导致磷酸肌酸、谷胱甘肽、牛磺酸、总胆碱、总肌酸的浓度降低（P < 0.01）以及[谷氨酸]/[谷氨酰胺]比值降低（P < 0.05）。在海马体（P < 0.01）和纹状体（P < 0.05）中观察到牛磺酸浓度较低。IUGR对P7大鼠脑区的神经化学特征有不同影响。持续的神经化学变化可能导致人类IUGR婴儿出现基于皮层的长期神经发育缺陷。
