使用高烯醇化物环化反应通过N-杂环卡宾催化的β-内酯稠合环戊烷的非对映选择性合成
N-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction.
作者信息
Mukherjee Subrata, Mondal Santigopal, Patra Atanu, Gonnade Rajesh G, Biju Akkattu T
机构信息
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India.
出版信息
Chem Commun (Camb). 2015 Jun 11;51(46):9559-62. doi: 10.1039/c5cc02960k.
PMID:25972189
Abstract
NHC-catalyzed annulation of enals with 2-enoylpyridines or 2-enoylpyridine N-oxides leading to the diastereoselective synthesis of β-lactone-fused cyclopentanes is reported. The reaction proceeds via the generation of homoenolate equivalent intermediates and tolerates a broad range of functional groups.
摘要
据报道，NHC催化烯醛与2-烯酰基吡啶或2-烯酰基吡啶N-氧化物的环化反应可实现β-内酯稠合环戊烷的非对映选择性合成。该反应通过生成同烯醇负离子等价中间体进行，并且能耐受多种官能团。
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