Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7309-13. doi: 10.1002/anie.201203382. Epub 2012 Jun 14.
New DKR type: An N-heterocyclic carbene (NHC)-catalyzed dynamic kinetic resolution of racemic α-substituted β-keto esters has been developed. This method relies on the epimerization of an NHC-enol intermediate before subsequent aldol/acylation events. Highly substituted β-lactones are produced in good yield with good to excellent selectivities (see scheme).
新型 DKR 类型:已开发出一种 N-杂环卡宾 (NHC)-催化的外消旋 α-取代 β-酮酯的动态动力学拆分。该方法依赖于 NHC-烯醇中间体的外消旋化,然后再进行羟醛/酰化反应。高度取代的 β-内酰胺以良好至优异的选择性(参见方案)高产率得到。