Yoh Kathryn, Prywes Ron
Department of Biological Sciences, Columbia University , New York, NY , USA.
Front Endocrinol (Lausanne). 2015 Apr 28;6:51. doi: 10.3389/fendo.2015.00051. eCollection 2015.
The p53-related gene p63 is required for epithelial cell establishment and its expression is often altered in tumor cells. Great strides have been made in understanding the pathways and mechanisms that regulate p63 levels, such as the Wnt, Hedgehog, Notch, and EGFR pathways. We discuss here the multiple signaling pathways that control p63 expression as well as transcription factors and post-transcriptional mechanisms that regulate p63 levels. While a unified picture has not emerged, it is clear that the fine-tuning of p63 has evolved to carefully control epithelial cell differentiation and fate.
与p53相关的基因p63是上皮细胞形成所必需的，其表达在肿瘤细胞中常常发生改变。在理解调控p63水平的途径和机制方面已经取得了很大进展，例如Wnt、Hedgehog、Notch和EGFR途径。我们在此讨论控制p63表达的多种信号通路以及调控p63水平的转录因子和转录后机制。虽然尚未形成统一的图景，但很明显，p63的精细调节已经进化到可以精确控制上皮细胞的分化和命运。
