Yu Haixin, Wang Yan, Yu Qian, Zhang Haiyan, Ma Wenduan, Shang Shengtao, Wang Donglin
Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, China.
Department of Pharmacy, China-Japan Union Hospital of Jilin University Changchun 130033, China.
Int J Clin Exp Pathol. 2015 Feb 1;8(2):2063-7. eCollection 2015.
We aimed to figure out the difference of serum hepatocyte growth factor (S-HGF) level between benign and malignant solitary pulmonary nodules (SPNs) patients.
The study comprised 42 serum samples from SPNs patients and 10 serum samples of healthy donors. The HGF level was measured by the commercially enzyme-linked immunosorbent assay (ELISA) kit.
By statistical analysis, the S-HGF levels of the malignant SPNs patients were significantly higher than that of control group (P < 0.05). Moreover, the levels of S-HGF in malignant group were also significantly higher than that in benign group (P < 0.05), while there was no significant difference between the benign and control group (P > 0.05). The levels of S-HGF were also shown no statistically significant difference (P > 0.05) in different pathologic types of lung cancer patients. In addition, the incidence of malignant SPNs increased when the S-HGF level ≥ 250 pg/ml.
The detection of S-HGF level may be a new detection method used for the rapid diagnosis of benign and malignant SPNs.
我们旨在明确良性和恶性孤立性肺结节（SPN）患者血清肝细胞生长因子（S-HGF）水平的差异。
该研究包括42例SPN患者的血清样本和10例健康供体的血清样本。采用商业酶联免疫吸附测定（ELISA）试剂盒测量HGF水平。
通过统计分析，恶性SPN患者的S-HGF水平显著高于对照组（P<0.05）。此外，恶性组的S-HGF水平也显著高于良性组（P<0.05），而良性组与对照组之间无显著差异（P>0.05）。不同病理类型的肺癌患者S-HGF水平也无统计学显著差异（P>0.05）。此外，当S-HGF水平≥250 pg/ml时，恶性SPN的发生率增加。
检测S-HGF水平可能是一种用于快速诊断良性和恶性SPN的新检测方法。
