Stervbo Ulrik, Roch Toralf, Westhoff Timm H, Gayova Ludmyla, Kurchenko Andrii, Seibert Felix S, Babel Nina
Center for Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospitals of the Ruhr-University of Bochum, Herne, Germany.
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
Front Physiol. 2019 Apr 17;10:402. doi: 10.3389/fphys.2019.00402. eCollection 2019.
Space flights, some physical activities, and extreme sports can greatly alter the gravitational forces experienced by the body. Being a deviation from the constant pull of Earth, these alterations can be considered gravitational stress and have the potential to affect physiological processes. Physical cues play a vital role in the homeostasis and function of the immune system. The effect of recurrent alterations of the gravitational pull on the levels of soluble mediator such as cytokines is unknown. Parabolic flights provide a controlled environment and make these a suitable model to study the effects of gravitational stress. Utilizing this model, we evaluated the effects of short-term gravitational stress on serum concentration of cytokines and other soluble mediators. Blood was taken from 12 healthy volunteers immediately before the first parabola and immediately after the last. Samples taken on the ground at corresponding time points the day before were used to control for circadian effects. A wide range of soluble mediators was analyzed using a multiplex bead assay. We found that the rate-change of eight molecules was significantly affected by the parabolic flight. Among other functions, these molecules, EGF, PDGF-AA, PDGF-BB, HGF, IP-10, Eotaxin (CCL11), TARC, and Angiopoietin-2, can be associated with bone remodeling and immune activation. It is therefore possible that gravitational stress can have clinically relevant impact on the control of a wide range of physiological processes.
太空飞行、一些体育活动和极限运动能极大地改变身体所经历的引力。作为对地球恒定引力的偏离，这些改变可被视为引力应激，并有可能影响生理过程。物理信号在免疫系统的稳态和功能中起着至关重要的作用。反复改变引力对细胞因子等可溶性介质水平的影响尚不清楚。抛物线飞行提供了一个可控环境，使其成为研究引力应激影响的合适模型。利用这个模型，我们评估了短期引力应激对细胞因子和其他可溶性介质血清浓度的影响。在第一次抛物线飞行前和最后一次抛物线飞行后立即从12名健康志愿者身上采集血液。前一天在相应时间点在地面采集的样本用于控制昼夜节律效应。使用多重微珠分析法分析了多种可溶性介质。我们发现，八种分子的变化率受到抛物线飞行的显著影响。在其他功能中，这些分子，即表皮生长因子（EGF）、血小板衍生生长因子-AA（PDGF-AA）、血小板衍生生长因子-BB（PDGF-BB）、肝细胞生长因子（HGF）、干扰素γ诱导蛋白10（IP-10）、嗜酸性粒细胞趋化因子（CCL11）、胸腺和活化调节趋化因子（TARC）以及血管生成素-2，可能与骨重塑和免疫激活有关。因此，引力应激可能对多种生理过程的控制产生临床相关影响。
