Chen Dongquan, Li Yufeng, Wang Lizhong, Jiao Kai
Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA ; Comprehensive Cancer Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Comprehensive Cancer Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA ; Research Division, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Int J Breast Cancer. 2015;2015:539721. doi: 10.1155/2015/539721. Epub 2015 Apr 20.
Breast cancer (BC) is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of BC metastasis is, however, far from complete. Identification of new factors during metastasis is an essential step towards future therapy. Our labs have focused on Semaphorin 6D (SEMA6D), which was implicated in immune responses, heart development, and neurogenesis. It will be interesting to know SEMA6D-related genomic expression profile and its implications in clinical outcome. In this study, we examined the public datasets of breast invasive carcinoma from The Cancer Genome Atlas (TCGA). We analyzed the expression of SEMA6D along with its related genes, their functions, pathways, and potential as copredictors for BC patients' survival. We found 6-gene expression profile that can be used as such predictors. Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression. The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.
乳腺癌（BC）是美国女性中第二常见的诊断癌症，也是女性癌症死亡的第二大主要原因。研究主要集中在BC转移方面。多种信号通路与BC转移的调控有关。然而，我们对BC转移调控的了解还远远不够完整。识别转移过程中的新因素是未来治疗的关键一步。我们实验室一直专注于信号素6D（SEMA6D），它与免疫反应、心脏发育和神经发生有关。了解SEMA6D相关的基因组表达谱及其对临床结果的影响将很有趣。在本研究中，我们检查了来自癌症基因组图谱（TCGA）的乳腺浸润癌公共数据集。我们分析了SEMA6D及其相关基因的表达、它们的功能、通路以及作为BC患者生存共同预测指标的潜力。我们发现了一个可用作此类预测指标的6基因表达谱。我们的研究首次提供证据表明乳腺浸润癌可能包含基于SEMA6D表达的一个亚型。SEMA6D基因的表达可能在促进患者生存方面发挥重要作用，尤其是在三阴性乳腺癌患者中。
