Arnhold Stefan, Wenisch Sabine
Department of Veterinary Anatomy-, Histology and -Embryology, University of Giessen Giessen, Germany.
Department of Veterinary Clinical Sciences, Small Animal Clinic c/o Institute of Veterinary Anatomy-, Histology and -Embryology, University of Giessen Frankfurter Str. 98. 35394, Giessen, Germany.
Am J Stem Cells. 2015 Mar 15;4(1):1-12. eCollection 2015.
Adipose tissue derived stem cells (ASCs) are mesenchymal stem cells which can be obtained from different adipose tissue sources within the body. It is an abundant cell pool, which is easy accessible and the cells can be obtained in large numbers, cultivated and expanded in vitro and prepared for tissue engineering approaches, especially for skeletal tissue repair. In the recent years this cell population has attracted a great amount of attention among researchers in human as well as in veterinary medicine. In the meantime ASCs have been well characterized and their use in regenerative medicine is very well established. This review focuses on the characterization of ASCs for their use for tissue engineering approaches especially in veterinary medicine and also highlights a selection of clinical trials on the basis of ASCs as the relevant cell source.
脂肪组织来源的干细胞(ASCs)是间充质干细胞,可从体内不同的脂肪组织来源获取。它是一个丰富的细胞库,易于获取,细胞可大量获得,能在体外培养和扩增,并用于组织工程方法,特别是用于骨骼组织修复。近年来,这一细胞群体在人类和兽医学研究人员中引起了极大关注。与此同时,ASCs已得到充分表征,其在再生医学中的应用也已非常成熟。本综述重点关注用于组织工程方法(特别是在兽医学中)的ASCs的表征,并突出了一些以ASCs作为相关细胞来源的临床试验。