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源自干细胞的细胞培养肉能为可持续的替代蛋白质铺平道路吗?

Can cell-cultured meat from stem cells pave the way for sustainable alternative protein?

作者信息

Nunes Octavio Bignardi da Silva, Buranello Tiago Willian, Farias Fabiana de Andrade, Rosero Jenyffer, Recchia Kaiana, Bressan Fabiana Fernandes

机构信息

Department of Food Engineering, Faculty of Animal Sciences and Food Engineering, University of São Paulo 13635-000, Pirassununga, SP, Brazil.

Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo 13635-000, Pirassununga, SP, Brazil.

出版信息

Curr Res Food Sci. 2025 Jan 21;10:100979. doi: 10.1016/j.crfs.2025.100979. eCollection 2025.

Abstract

As the global population grows, the demand for food and animal-derived products rises significantly, posing a notable challenge to the progress of society in general. Alternative protein production may adequately address such a challenge, and cell-based meat production emerges as a promising solution. This review investigates methodologies for myogenesis and adipogenesis from stem cells (adult, embryonic, or induced pluripotent stem cells - iPSCs) across different animal species, as well as the remaining challenges for scalability, the possibility of genetic modification, along with safety concerns regarding the commercialization of cell-cultured meat. Regarding such complexities, interdisciplinary approaches will be vital for assessing the potential of cell-cultured meat as a sustainable protein source, mimicking the sensory and nutritional attributes of conventional livestock meat whilst meeting the demands of a growing global population while mitigating environmental impacts.

摘要

随着全球人口增长,对食品和动物源产品的需求显著上升,这给整个社会的发展带来了重大挑战。替代蛋白生产或许能充分应对这一挑战,基于细胞的肉类生产成为一个有前景的解决方案。本综述研究了不同动物物种干细胞(成体、胚胎或诱导多能干细胞-iPSCs)的成肌和成脂方法,以及扩大规模面临的剩余挑战、基因改造的可能性,还有关于细胞培养肉商业化的安全问题。考虑到这些复杂性,跨学科方法对于评估细胞培养肉作为可持续蛋白质来源的潜力至关重要,它能模仿传统家畜肉的感官和营养特性,同时满足不断增长的全球人口需求,减轻对环境的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b73a/11878651/93f5384ce5a8/ga1.jpg

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