Beyond association: A functional role for Tcf7l2 in β-cell development.
作者信息
Migliorini Adriana, Lickert Heiko
机构信息
Institute of Stem Cell Research (ISF), Helmholtz Center, Munich, Germany ; Institute of Diabetes and Regeneration (IDR), Helmholtz Center, Munich, Germany.
Institute of Stem Cell Research (ISF), Helmholtz Center, Munich, Germany ; Institute of Diabetes and Regeneration (IDR), Helmholtz Center, Munich, Germany ; Technical University Munich (TUM), Germany ; German Center for Diabetes Research (DZD), Germany ; Helmholtz Alliance ICEMED - Imaging and Curing Environmental Metabolic Diseases.(ICEMED), Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
出版信息
Mol Metab. 2015 Mar 17;4(5):365-6. doi: 10.1016/j.molmet.2015.03.002. eCollection 2015 May.
Abstract
摘要
相似文献
1
Beyond association: A functional role for Tcf7l2 in β-cell development.超越关联：Tcf7l2在β细胞发育中的功能作用
Mol Metab. 2015 Mar 17;4(5):365-6. doi: 10.1016/j.molmet.2015.03.002. eCollection 2015 May.
2
The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis.胚胎期胰腺β细胞中显性负性TCF7L2的表达会导致葡萄糖稳态受损。
Mol Metab. 2015 Feb 4;4(4):344-52. doi: 10.1016/j.molmet.2015.01.008. eCollection 2015 Apr.
3
Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway.京尼平苷通过调节β-连环蛋白/TCF7L2信号通路促进β细胞再生和存活。
Cell Death Dis. 2015 May 7;6(5):e1746. doi: 10.1038/cddis.2015.107.
4
Variants and haplotypes of TCF7L2 are associated with β-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.TCF7L2 的变异和单倍型与新诊断 2 型糖尿病患者的β细胞功能相关：维罗纳新诊断 2 型糖尿病研究（VNDS）1。
J Clin Endocrinol Metab. 2011 Feb;96(2):E389-93. doi: 10.1210/jc.2010-1677. Epub 2010 Dec 15.
5
TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.TCF7L2 基因多态性与 2 型糖尿病：与糖尿病视网膜病变和心血管自主神经病变的关系。
Acta Diabetol. 2013 Oct;50(5):789-99. doi: 10.1007/s00592-012-0418-x. Epub 2012 Jul 28.
6
Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.法国人群中转录因子TCF7L2的遗传学研究：在人β细胞和脂肪组织中的表达及其与2型糖尿病的强关联
Diabetes. 2006 Oct;55(10):2903-8. doi: 10.2337/db06-0474.
7
DIF-1 inhibits the Wnt/β-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines.DIF-1 通过抑制结肠癌细胞系中 TCF7L2 的表达来抑制 Wnt/β-catenin 信号通路。
Biochem Pharmacol. 2012 Jan 1;83(1):47-56. doi: 10.1016/j.bcp.2011.10.001. Epub 2011 Oct 8.
8
[Association between polymorphisms of TCF7L2 and type 2 diabetes with special reference to incretin action].[TCF7L2基因多态性与2型糖尿病的关联及对肠促胰岛素作用的特别参考]
Nihon Rinsho. 2011 May;69(5):930-6.
9
Association of LRP5, TCF7L2, and GCG variants and type 2 diabetes mellitus as well as fasting plasma glucose and lipid metabolism indexes.LRP5、TCF7L2和GCG基因变异与2型糖尿病以及空腹血糖和脂质代谢指标的关联
Hum Immunol. 2015 May;76(5):339-43. doi: 10.1016/j.humimm.2015.03.005. Epub 2015 Apr 8.
10
The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus.Wnt信号通路效应因子TCF7L2与2型糖尿病
Mol Endocrinol. 2008 Nov;22(11):2383-92. doi: 10.1210/me.2008-0135. Epub 2008 Jul 3.
引用本文的文献
1
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice.肝细胞中的 Tcf7l2 调控饮食诱导的非酒精性脂肪性肝病小鼠模型中的从头脂肪生成。
Diabetologia. 2023 May;66(5):931-954. doi: 10.1007/s00125-023-05878-8. Epub 2023 Feb 10.
2
TCF7L2 polymorphisms are associated with amygdalar volume in elderly individuals with Type 2 Diabetes.TCF7L2 多态性与 2 型糖尿病老年个体杏仁核体积相关。
Sci Rep. 2019 Nov 1;9(1):15818. doi: 10.1038/s41598-019-48899-3.
3
TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway.TCF7L2通过PI3K/AKT信号通路调节胰腺β细胞功能。
Diabetol Metab Syndr. 2019 Jul 5;11:55. doi: 10.1186/s13098-019-0449-3. eCollection 2019.
4
Transcription Factor 7-Like 2 () Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.转录因子 7 样 2（）基因多态性与 1 型糖尿病高危个体中从单一自身抗体阳性向多种自身抗体阳性的进展。
Diabetes Care. 2018 Dec;41(12):2480-2486. doi: 10.2337/dc18-0861. Epub 2018 Oct 1.
5
A genetic risk score that includes common type 2 diabetes risk variants is associated with gestational diabetes.包含常见2型糖尿病风险变异的遗传风险评分与妊娠期糖尿病相关。
Clin Endocrinol (Oxf). 2017 Aug;87(2):149-155. doi: 10.1111/cen.13356. Epub 2017 May 26.
6
Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder.初步证据表明，肾上腺素能神经系统在广泛性焦虑障碍中起作用。
Sci Rep. 2017 Feb 15;7:42676. doi: 10.1038/srep42676.
7
Candidate gene analysis supports a role for polymorphisms at TCF7L2 as risk factors for type 2 diabetes in Sudan.候选基因分析支持TCF7L2基因多态性作为苏丹2型糖尿病危险因素的作用。
J Diabetes Metab Disord. 2016 Mar 1;15:4. doi: 10.1186/s40200-016-0225-y. eCollection 2015.
本文引用的文献
1
The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis.胚胎期胰腺β细胞中显性负性TCF7L2的表达会导致葡萄糖稳态受损。
Mol Metab. 2015 Feb 4;4(4):344-52. doi: 10.1016/j.molmet.2015.01.008. eCollection 2015 Apr.
2
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.胰腺β细胞中Tcf7l2的选择性破坏会损害分泌功能并降低β细胞量。
Hum Mol Genet. 2015 Mar 1;24(5):1390-9. doi: 10.1093/hmg/ddu553. Epub 2014 Oct 29.
3
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.糖尿病风险基因和 Wnt 效应物 Tcf7l2/TCF4 控制肝脏对围产期和成年代谢需求的反应。
Cell. 2012 Dec 21;151(7):1595-607. doi: 10.1016/j.cell.2012.10.053.
4
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.胰腺特异性 Tcf7l2 基因敲除小鼠存在葡萄糖耐量异常和胰岛素分泌异常。
Diabetologia. 2012 Oct;55(10):2667-2676. doi: 10.1007/s00125-012-2600-7. Epub 2012 Jun 21.
5
Wnt signaling, stem cells, and cancer of the gastrointestinal tract.Wnt 信号转导、干细胞与胃肠道肿瘤
Cold Spring Harb Perspect Biol. 2012 Apr 1;4(4):a007989. doi: 10.1101/cshperspect.a007989.
6
TCF7L2 splice variants have distinct effects on beta-cell turnover and function.TCF7L2 剪接变异体对β细胞的更新和功能有不同的影响。
Hum Mol Genet. 2011 May 15;20(10):1906-15. doi: 10.1093/hmg/ddr072. Epub 2011 Feb 28.
7
Cellular plasticity within the pancreas--lessons learned from development.胰腺中的细胞可塑性——从发育中得到的启示。
Dev Cell. 2010 Mar 16;18(3):342-56. doi: 10.1016/j.devcel.2010.02.005.
8
Wnt signaling in pancreatic islets.Wnt 信号在胰岛中的作用。
Adv Exp Med Biol. 2010;654:391-419. doi: 10.1007/978-90-481-3271-3_17.
9
Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.2型糖尿病中TCF7L2蛋白水平降低与GIP和GLP-1受体下调及β细胞功能受损相关。
Hum Mol Genet. 2009 Jul 1;18(13):2388-99. doi: 10.1093/hmg/ddp178. Epub 2009 Apr 21.
10
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation.胰高血糖素样肽-1激活依赖TCF7L2的Wnt信号通路可增强胰腺β细胞增殖。
J Biol Chem. 2008 Mar 28;283(13):8723-35. doi: 10.1074/jbc.M706105200. Epub 2008 Jan 23.
Zotero 插件