胰腺中的细胞可塑性——从发育中得到的启示。
Cellular plasticity within the pancreas--lessons learned from development.
机构信息
Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.
出版信息
Dev Cell. 2010 Mar 16;18(3):342-56. doi: 10.1016/j.devcel.2010.02.005.
Abstract
The pancreas has been the subject of intense research due to the debilitating diseases that result from its dysfunction. In this review, we summarize current understanding of the critical tissue interactions and intracellular regulatory events that take place during formation of the pancreas from a small cluster of cells in the foregut domain of the mouse embryo. Importantly, an understanding of principles that govern the development of this organ has equipped us with the means to manipulate both embryonic and differentiated adult cells in the context of regenerative medicine. The emerging area of lineage modulation within the adult pancreas is of particular interest, and this review summarizes recent findings that exemplify how lessons learned from development are being applied to reveal the potential of fully differentiated cells to change fate.
摘要
由于胰腺功能障碍会导致多种使人虚弱的疾病，因此胰腺一直是研究的热点。在这篇综述中，我们总结了目前对于从小鼠胚胎前肠区域的一小簇细胞形成胰腺的过程中发生的关键组织相互作用和细胞内调节事件的理解。重要的是，对于控制该器官发育的原理的认识，使我们能够在再生医学的背景下操纵胚胎和分化的成年细胞。成年胰腺中谱系调节的新兴领域尤其引人注目，本综述总结了最近的发现，这些发现例证了从发育中获得的经验教训如何被应用于揭示完全分化的细胞改变命运的潜力。
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