蓝藻作为细胞工厂生产植物次生代谢产物。
Cyanobacteria as cell factories to produce plant secondary metabolites.
机构信息
Department of Applied Science, University of Arkansas at Little Rock , Little Rock, AR , USA.
出版信息
Front Bioeng Biotechnol. 2015 Apr 28;3:57. doi: 10.3389/fbioe.2015.00057. eCollection 2015.
Cyanobacteria represent a promising platform for the production of plant secondary metabolites. Their capacity to express plant P450 proteins, which have essential functions in the biosynthesis of many plant secondary metabolites, makes cyanobacteria ideal for this purpose, and their photosynthetic capability allows cyanobacteria to grow with simple nutrient inputs. This review summarizes the advantages of using cyanobacteria to transgenically produce plant secondary metabolites. Some techniques to improve heterologous gene expression in cyanobacteria are discussed.
蓝藻是生产植物次生代谢产物的有前途的平台。它们能够表达植物 P450 蛋白，而 P450 蛋白在许多植物次生代谢产物的生物合成中具有重要功能，这使得蓝藻成为实现这一目标的理想选择，而且它们的光合作用能力使得蓝藻能够在简单的营养输入下生长。本文总结了利用蓝藻转基因生产植物次生代谢产物的优势，并讨论了一些提高蓝藻中异源基因表达的技术。
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