Gong Juan, Jiang Yuan, Hao Ningbo, Zhu Bo, Li Yongsheng
Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Sci Rep. 2015 May 14;5:10111. doi: 10.1038/srep10111.
Axin2 is involved in the regulation of Wnt/β-catenin pathway and implicated in cancer development and progression. The association between AXIN2 rs2240308 polymorphism and cancer risk has been examined in several case-control studies, but the conclusions were conflicting. Here we performed a meta-analysis to evaluate the role of rs2240308 in cancer risk. A total of 8 studies were included in this meta-analysis (1559 cancer cases and 1503 controls). The pooled odds ratios (OR) and the 95% confidence intervals (CIs) were assessed to evaluate the association of the AXIN2 rs2240308 polymorphism with a susceptibility to cancer. A significantly decreased overall cancer risk was observed in the homozygous (TT vs. CC), heterozygous (CT vs. CC), dominant (CT+TT vs. CC) and allelic (T vs. C) models (P < 0.005), rather than that in the recessive (TT vs. CT+CC) model (P = 0.092). AXIN2 polymorphism rs2240308 was also associated with decreased cancer risk under all five models in lung cancer. However, AXIN2 rs2240308 polymorphism was not associated with cancer risk under any above model in Turkish population and under homozygous, heterozygous, recessive models in Japanese population. These findings indicate that AXIN2 rs2240308 polymorphism significantly and race-specifically correlates with decreased cancer risk.
Axin2参与Wnt/β-连环蛋白信号通路的调控，并与癌症的发生和发展有关。几项病例对照研究检测了AXIN2 rs2240308多态性与癌症风险之间的关联，但结论相互矛盾。在此，我们进行了一项荟萃分析，以评估rs2240308在癌症风险中的作用。本荟萃分析共纳入8项研究（1559例癌症病例和1503例对照）。通过评估合并比值比（OR）和95%置信区间（CI）来评价AXIN2 rs2240308多态性与癌症易感性的关联。在纯合子（TT vs. CC）、杂合子（CT vs. CC）、显性（CT+TT vs. CC）和等位基因（T vs. C）模型中观察到总体癌症风险显著降低（P < 0.005），而在隐性（TT vs. CT+CC）模型中未观察到显著降低（P = 0.092）。在肺癌的所有五种模型下，AXIN2多态性rs2240308也与癌症风险降低相关。然而，在土耳其人群中，AXIN2 rs2240308多态性在上述任何模型下均与癌症风险无关；在日本人群中，AXIN2 rs2240308多态性在纯合子、杂合子、隐性模型下与癌症风险无关。这些发现表明，AXIN2 rs2240308多态性与癌症风险降低显著相关，且具有种族特异性。
