AXIN2 s2240308 C>T、rs1133683 C>T、rs7224837 A>G 多态性与乳腺癌易感性的关联。
Association of AXIN2 s2240308 C>T, rs1133683 C>T, rs7224837 A>G Polymorphisms with Susceptibility to Breast Cancer.
机构信息
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Department of Biology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
出版信息
Asian Pac J Cancer Prev. 2021 Aug 1;22(8):2717-2722. doi: 10.31557/APJCP.2021.22.8.2717.
BACKGROUND
The association of genetic polymorphisms at Axis inhibition protein 2 (AXIN2) gene and susceptibility to different cancer has attracted much interest. The present study aimed to evaluate the association between AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G polymorphisms with susceptibility to breast cancer.
METHODS
A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was designed to genotype the AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G polymorphisms among 150 breast cancer patients and 150 healthy subjects.
RESULTS
The frequencies of these genetic variants were in agreement with Hardy-Weinberg equilibrium in healthy controls (p>0.05). The frequencies of AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G genotypes were similar in breast cancer patients and controls. There was no a significant association between the AXIN2 SNP and risk of breast cancer.
CONCLUSION
The impact of AXIN2 polymorphisms in the breast cancer development remains unclear. Our results indicated that AXIN2 rs2240308, rs7224837 and rs1133683 polymorphisms did not contribute to increased risk of breast cancer. More studies with larger sample sizes and diverse ethnicities are warranted to verify our finding.
背景
轴抑制蛋白 2（AXIN2）基因遗传多态性与多种癌症易感性的关联引起了广泛关注。本研究旨在评估 AXIN2 rs2240308 C>T、rs1133683 C>T、rs7224837 A>G 多态性与乳腺癌易感性的关系。
方法
设计聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析，对 150 例乳腺癌患者和 150 例健康对照者的 AXIN2 rs2240308 C>T、rs1133683 C>T、rs7224837 A>G 多态性进行基因分型。
结果
这些遗传变异在健康对照组中符合 Hardy-Weinberg 平衡（p>0.05）。AXIN2 rs2240308 C>T、rs1133683 C>T、rs7224837 A>G 基因型在乳腺癌患者和对照组中的频率相似。AXIN2 SNP 与乳腺癌风险之间无显著关联。
结论
AXIN2 多态性对乳腺癌发生的影响尚不清楚。我们的结果表明，AXIN2 rs2240308、rs7224837 和 rs1133683 多态性与乳腺癌风险增加无关。需要更大样本量和更多种族的研究来验证我们的发现。
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