Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Cell Host Microbe. 2015 May 13;17(5):540-1. doi: 10.1016/j.chom.2015.04.012.
During colitis, gut bacteria and bacterial components can traverse the mucus layer and contact host cells. In this issue of Cell Host & Microbe, Hickey et al. (2015) show that sulfatases of Bacteroides thetaiotaomicron are required for its outer membrane vesicles to transit to underlying host immune cells and cause colitis.
在结肠炎发生过程中，肠道细菌和细菌成分可以穿透黏液层并与宿主细胞接触。在本期《细胞宿主与微生物》中，Hickey 等人（2015）表明，拟杆菌属的硫酸盐酶对于其外膜囊泡向下方的宿主免疫细胞转移并导致结肠炎是必需的。
