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Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles.致结肠炎的嗜黏蛋白阿克曼氏菌抗原通过外膜囊泡以硫酸酯酶依赖性方式进入宿主免疫细胞。
Cell Host Microbe. 2015 May 13;17(5):672-80. doi: 10.1016/j.chom.2015.04.002.
2
Friend turned foe: a role for bacterial sulfatases in colitis.从朋友到敌人：细菌硫酸盐酶在结肠炎中的作用。
Cell Host Microbe. 2015 May 13;17(5):540-1. doi: 10.1016/j.chom.2015.04.012.
3
Bacterial pathogenesis. Message in a bottle.细菌致病机制。瓶中信。
Nat Rev Microbiol. 2015 Jul;13(7):400. doi: 10.1038/nrmicro3510. Epub 2015 Jun 8.
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Mucosal immunology: Message in a bottle.黏膜免疫学：瓶中信
Nat Rev Immunol. 2015 Jul;15(7):402. doi: 10.1038/nri3872. Epub 2015 Jun 5.
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Sulfatases and a radical S-adenosyl-L-methionine (AdoMet) enzyme are key for mucosal foraging and fitness of the prominent human gut symbiont, Bacteroides thetaiotaomicron.硫酸盐酶和一种活性的 S-腺苷-L-甲硫氨酸（AdoMet）酶是突出的人类肠道共生菌拟杆菌（Bacteroides thetaiotaomicron）进行黏膜觅食和适应的关键。
J Biol Chem. 2011 Jul 22;286(29):25973-82. doi: 10.1074/jbc.M111.228841. Epub 2011 Apr 20.
6
The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen.共生拟杆菌 Thetaiotaomicron 的结肠炎相关转录谱增强了对细菌抗原的适应性免疫反应。
PLoS One. 2012;7(8):e42645. doi: 10.1371/journal.pone.0042645. Epub 2012 Aug 3.
7
Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase.对来自人类肠道共生菌多形拟杆菌的糖胺聚糖（GAG）硫酸酯酶的表征揭示了首个GAG特异性细菌内切硫酸酯酶。
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Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease.拟杆菌属厚壁菌门来源的外膜囊泡促进健康个体中的调节性树突状细胞应答，但在炎症性肠病中则不然。
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Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against β-lactam antibiotics.与拟杆菌属释放的外膜囊泡相关的头孢菌素酶可保护肠道病原体和共生菌免受β-内酰胺抗生素的影响。
J Antimicrob Chemother. 2015 Mar;70(3):701-9. doi: 10.1093/jac/dku466. Epub 2014 Nov 27.
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The effect of saturated and unsaturated fatty acids on the production of outer membrane vesicles from and .饱和脂肪酸和不饱和脂肪酸对[具体来源]外膜囊泡产生的影响。 （注：原文中“from and ”表述不完整，可能影响准确理解）
Gastroenterol Hepatol Bed Bench. 2019 Spring;12(2):155-162.

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Dietary carbohydrates alter immune-modulatory functionalities and DNA inversions in Bacteroides thetaiotaomicron.膳食碳水化合物会改变嗜热栖热放线菌的免疫调节功能和DNA倒位。
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Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages.肠道拟杆菌目的适应性变化有助于与它们的裂解性噬菌体稳定共存。
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Characterization of proteins present in the biofilm matrix and outer membrane vesicles of during iron-sufficient and iron-restricted growth: identification of potential protective antigens through analyses.铁充足和铁限制生长期间生物膜基质和外膜囊泡中存在的蛋白质的表征：通过分析鉴定潜在的保护性抗原。
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本文引用的文献

1
Host-microbe interactions shaping the gastrointestinal environment.宿主-微生物相互作用塑造胃肠道环境。
Trends Immunol. 2014 Nov;35(11):538-48. doi: 10.1016/j.it.2014.08.002. Epub 2014 Sep 11.
2
Multifunctional nutrient-binding proteins adapt human symbiotic bacteria for glycan competition in the gut by separately promoting enhanced sensing and catalysis.多功能营养结合蛋白通过分别促进增强的感知和催化作用，使人类共生细菌适应肠道中的聚糖竞争。
mBio. 2014 Sep 9;5(5):e01441-14. doi: 10.1128/mBio.01441-14.
3
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.白细胞介素-10 受体信号在先天免疫细胞中调节黏膜免疫耐受和抗炎性巨噬细胞功能。
Immunity. 2014 May 15;40(5):706-19. doi: 10.1016/j.immuni.2014.03.011. Epub 2014 May 1.
4
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.免疫受体 NOD1 和激酶 RIP2 与早期内体上的细菌肽聚糖相互作用，以促进自噬和炎症信号转导。
Cell Host Microbe. 2014 May 14;15(5):623-35. doi: 10.1016/j.chom.2014.04.001. Epub 2014 Apr 17.
5
Preferential packing of acidic glycosidases and proteases into Bacteroides outer membrane vesicles.酸性糖苷酶和蛋白酶优先包装到拟杆菌的外膜囊泡中。
mBio. 2014 Mar 11;5(2):e00909-14. doi: 10.1128/mBio.00909-14.
6
Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.鼠胃、小肠和结肠黏液的研究。III. 胃肠道 Muc5ac 和 Muc2 粘蛋白 O-聚糖模式揭示了区域特异性分布。
Am J Physiol Gastrointest Liver Physiol. 2013 Sep 1;305(5):G357-63. doi: 10.1152/ajpgi.00048.2013. Epub 2013 Jul 5.
7
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.琥珀酸是一种炎症信号，通过 HIF-1α 诱导 IL-1β 的表达。
Nature. 2013 Apr 11;496(7444):238-42. doi: 10.1038/nature11986. Epub 2013 Mar 24.
8
The gastrointestinal mucus system in health and disease.健康与疾病中的胃肠道黏液系统。
Nat Rev Gastroenterol Hepatol. 2013 Jun;10(6):352-61. doi: 10.1038/nrgastro.2013.35. Epub 2013 Mar 12.
9
Quantitative and qualitative preparations of bacterial outer membrane vesicles.细菌外膜囊泡的定量和定性制备。
Methods Mol Biol. 2013;966:259-72. doi: 10.1007/978-1-62703-245-2_16.
10
Outer membrane vesicles of a human commensal mediate immune regulation and disease protection.人体共生菌的外膜囊泡可进行免疫调节并预防疾病。
Cell Host Microbe. 2012 Oct 18;12(4):509-20. doi: 10.1016/j.chom.2012.08.004. Epub 2012 Sep 20.

致结肠炎的嗜黏蛋白阿克曼氏菌抗原通过外膜囊泡以硫酸酯酶依赖性方式进入宿主免疫细胞。

Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles.

作者信息

Hickey Christina A, Kuhn Kristine A, Donermeyer David L, Porter Nathan T, Jin Chunsheng, Cameron Elizabeth A, Jung Haerin, Kaiko Gerard E, Wegorzewska Marta, Malvin Nicole P, Glowacki Robert W P, Hansson Gunnar C, Allen Paul M, Martens Eric C, Stappenbeck Thaddeus S

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

出版信息

Cell Host Microbe. 2015 May 13;17(5):672-80. doi: 10.1016/j.chom.2015.04.002.

DOI:10.1016/j.chom.2015.04.002
PMID:25974305
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4432250/
Abstract

Microbes interact with the host immune system via several potential mechanisms. One essential step for each mechanism is the method by which intestinal microbes or their antigens access specific host immune cells. Using genetically susceptible mice (dnKO) that develop spontaneous, fulminant colitis, triggered by Bacteroides thetaiotaomicron (B. theta), we investigated the mechanism of intestinal microbial access under conditions that stimulate colonic inflammation. B. theta antigens localized to host immune cells through outer membrane vesicles (OMVs) that harbor bacterial sulfatase activity. We deleted the anaerobic sulfatase maturating enzyme (anSME) from B. theta, which is required for post-translational activation of all B. theta sulfatase enzymes. This bacterial mutant strain did not stimulate colitis in dnKO mice. Lastly, access of B. theta OMVs to host immune cells was sulfatase dependent. These data demonstrate that bacterial OMVs and associated enzymes promote inflammatory immune stimulation in genetically susceptible hosts.

摘要

微生物通过多种潜在机制与宿主免疫系统相互作用。每种机制的一个关键步骤是肠道微生物或其抗原进入特定宿主免疫细胞的方式。我们使用因具核梭杆菌（B. theta）引发自发性暴发性结肠炎的基因易感小鼠（dnKO），研究了在刺激结肠炎症的条件下肠道微生物进入的机制。B. theta抗原通过具有细菌硫酸酯酶活性的外膜囊泡（OMV）定位于宿主免疫细胞。我们从B. theta中删除了厌氧硫酸酯酶成熟酶（anSME），这是所有B. theta硫酸酯酶翻译后激活所必需的。这种细菌突变株不会在dnKO小鼠中刺激结肠炎。最后，B. theta OMV进入宿主免疫细胞依赖于硫酸酯酶。这些数据表明，细菌OMV和相关酶在基因易感宿主中促进炎症性免疫刺激。