al-Mondhiry H, Pae W, Rosenberg G, Pierce W
Department of Medicine, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey 17033.
ASAIO Trans. 1989 Jul-Sep;35(3):238-41. doi: 10.1097/00002480-198907000-00019.
The purpose of this study was to assess hematologic abnormalities and thromboembolic complications related to long-term use of the pneumatic artificial heart (PAH). Laboratory data and autopsy findings were analyzed from 24 calves that survived 70-353 (150 +/- 82) days after implantation of a PAH. Compared with baseline levels, the hemoglobin was significantly lower, and the plasma hemoglobin and serum LDH significantly higher, throughout the follow-up period. The platelet count decreased during the first 10-30 weeks, but returned to preoperative levels by week 35. Platelet survival in 4 calves in stable condition was normal, and the leukocyte count and absolute neutrophil count were within normal limits. At autopsy, thrombotic complications and organ infarction were noted in 13 calves, and major septic complications were documented in 10 animals. The authors' observations indicate that thromboembolism and infection are major complications of long-term use of the PAH.
本研究的目的是评估与长期使用气动人工心脏（PAH）相关的血液学异常和血栓栓塞并发症。分析了24头小牛的实验室数据和尸检结果，这些小牛在植入PAH后存活了70 - 353（150±82）天。在整个随访期间，与基线水平相比，血红蛋白显著降低，血浆血红蛋白和血清乳酸脱氢酶显著升高。血小板计数在最初的10 - 30周内下降，但在第35周时恢复到术前水平。4头状况稳定的小牛的血小板存活正常，白细胞计数和绝对中性粒细胞计数在正常范围内。尸检时，13头小牛出现血栓并发症和器官梗死，10只动物记录有严重的败血症并发症。作者的观察表明，血栓栓塞和感染是长期使用PAH的主要并发症。
