Akizawa T, Kino K, Koshikawa S, Ikada Y, Kishida A, Yamashita M, Imamura K
Internal Medicine Department, Fujigaoka Hospital, Showa University, Yokohama, Japan.
ASAIO Trans. 1989 Jul-Sep;35(3):333-5. doi: 10.1097/00002480-198907000-00051.
Dialytic efficiency and biocompatibility of a new modified cellulose membrane (NMC) were examined in vitro and clinically. NMC was obtained by grafting polyethylene-glycol (PEG) chains to the membrane surface of ordinary cellulose (OC), and it was expected that the random movement of PEG chains would prevent blood cells and large plasma proteins from coming into contact with the membrane surface, resulting in improving the biocompatibility and thrombogenicity of the membrane. Surface characteristics of NMC were rendered anionic and hydrophilic, however, the activations of complement and platelet systems were clearly suppressed in NMC. Minimum heparin requirement for hemodialysis was significantly lower with NMC than with OC dialyzer. No significant difference in solute and water removal was observed between the two dialyzers. These results indicate that NMC can provide increased biocompatibility and antithrombogenic effect while retaining the essential dialysis efficiency of OC.
在体外和临床环境中对一种新型改性纤维素膜（NMC）的透析效率和生物相容性进行了检测。NMC是通过将聚乙二醇（PEG）链接枝到普通纤维素（OC）的膜表面而获得的，预计PEG链的随机运动会阻止血细胞和大的血浆蛋白与膜表面接触，从而提高膜的生物相容性和抗血栓形成性。NMC的表面特性呈阴离子性和亲水性，然而，NMC中补体和血小板系统的激活明显受到抑制。使用NMC进行血液透析时所需的最低肝素量明显低于使用OC透析器时。两种透析器在溶质和水分清除方面未观察到显著差异。这些结果表明，NMC在保持OC基本透析效率的同时，可以提高生物相容性和抗血栓形成作用。
