Woodard J C, Farrar D J, Chow E, Santamore W P, Burkhoff D, Hill J D
Department of Cardiovascular Surgery, Pacific Presbyterian Medical Center, San Francisco, California.
ASAIO Trans. 1989 Jul-Sep;35(3):439-41. doi: 10.1097/00002480-198907000-00086.
The authors used a computer model of the heart and circulation to test the hypothesis that anatomic ventricular interactions are responsible for the observed instances of right ventricular failure during use of a left ventricular assist device. The model predicts that left ventricular pressure-unloading with a LVAD, in the presence of isolated systolic interaction, results in impairment of RV function, whereas with isolated diastolic interaction, RV function is improved. Due to competition between these two interactions, there is a negligible overall effect of ventricular anatomic interactions in determining right ventricular function in the normal heart.
解剖学上的心室相互作用是使用左心室辅助装置期间观察到的右心室衰竭实例的原因。该模型预测，在存在孤立的收缩期相互作用的情况下，使用左心室辅助装置使左心室压力卸载会导致右心室功能受损，而在存在孤立的舒张期相互作用时，右心室功能会得到改善。由于这两种相互作用之间的竞争，在正常心脏中，心室解剖学相互作用对确定右心室功能的总体影响可忽略不计。
