Kim J K, Oh S Y, Sohn E H, Hong Y H, Jun S M, Bae J S
Department of Neurology, Dong-A University College of Medicine, Busan, Korea.
Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea.
J Peripher Nerv Syst. 2015 Mar;20(1):32-6. doi: 10.1111/jns.12115.
A variant of Guillain-Barré syndrome (GBS) with predominant manifestation of facial diplegia (FD) has been described recently. This study aimed to characterize and determine the incidence of this FD-predominant GBS variant. The clinical and serological information of 900 consecutive patients were reviewed. In total, eight patients were identified between January 2007 and December 2010 as having FD accompanied by some features of GBS. These features were subjective sensory symptoms such as distal paresthesia (7/8, 88%), albumin-cytological (A/C) dissociation (7/8, 88%), antecedent infection (6/8, 75%), and minor nerve conduction study (NCS) abnormalities (5/7, 71%). One patient presented with the typical NCS feature of demyelinating neuropathy. Only two patients exhibited areflexia (2/8, 25%). None of the patients possessed any anti-ganglioside antibodies; however, the serum of two patients was positive for anti-mycoplasma antibody (2/6, 33%). FD variant of GBS occurred in less than 1% of our dataset. FD can be a regional variant of GBS when it is accompanied by supporting features, such as subjective tingling, A/C dissociation, and minor NCS abnormalities.
最近报道了一种以面部双瘫（FD）为主要表现的吉兰-巴雷综合征（GBS）变异型。本研究旨在对这种以FD为主的GBS变异型进行特征描述并确定其发病率。回顾了900例连续患者的临床和血清学信息。2007年1月至2010年12月期间，共确定8例患者患有FD并伴有一些GBS特征。这些特征包括主观感觉症状，如远端感觉异常（7/8，88%）、蛋白细胞分离（A/C分离，7/8，88%）、前驱感染（6/8，75%）以及轻微神经传导研究（NCS）异常（5/7，71%）。1例患者表现出脱髓鞘性神经病的典型NCS特征。仅2例患者出现腱反射消失（2/8，25%）。所有患者均未检测到抗神经节苷脂抗体；然而，2例患者的血清抗支原体抗体呈阳性（2/6，33%）。在我们的数据集中，GBS的FD变异型发生率不到1%。当FD伴有诸如主观刺痛、A/C分离和轻微NCS异常等支持性特征时，可作为GBS的一种区域性变异型。
