Akyol Sumeyya, Isik Bunyamin, Altuntas Aynur, Erden Gonul, Cakmak Ozlem, Kurşunlu S Fatih, Adam Bahattin, Akyol Omer
Department of Medical Biology, Medical Faculty, Turgut Ozal University, Ankara 06170, Turkey.
Department of Family Medicine, Medical Faculty, Hacettepe University, Ankara 06100, Turkey.
Mol Med Rep. 2015 Sep;12(3):3231-3235. doi: 10.3892/mmr.2015.3785. Epub 2015 May 14.
Caffeic acid phenethyl ester (CAPE) is an important active component of propolis, which is derived from honeybee hives. It has received increasing attention in a variety of medical and pharmaceutical research, due to its anti‑oxidant, antiproliferative, anti‑inflammatory, antiviral and antifungal activity, in addition to its antineoplastic properties. Besides the use of CAPE as an antioxidant and anti‑inflammatory agent in a number of in vivo studies of ear disease, its beneficial effects have been reported in the treatment of cancer, arthritis, allergies, heart disease, diabetes, kidney disease, liver disease and neurological disease. CAPE influences a number of biochemical pathways, as well as several targets involved in ear diseases, in particular, in ototoxicity. The protective effects of CAPE in ototoxicity, which may be induced by a number factors, including lipopolysaccharides, hydrogen peroxide and streptomycin, are evaluated and discussed in the present review.
咖啡酸苯乙酯（CAPE）是蜂胶的一种重要活性成分，来源于蜂巢。由于其具有抗氧化、抗增殖、抗炎、抗病毒、抗真菌活性以及抗肿瘤特性，它在各种医学和药学研究中受到越来越多的关注。除了在多项耳部疾病的体内研究中用作抗氧化剂和抗炎剂外，据报道其在癌症、关节炎、过敏、心脏病、糖尿病、肾病、肝病和神经疾病的治疗中也有有益作用。CAPE影响多种生化途径以及一些与耳部疾病相关的靶点，特别是在耳毒性方面。本文综述评估并讨论了CAPE在可能由多种因素（包括脂多糖、过氧化氢和链霉素）诱导的耳毒性中的保护作用。
