Morcos Nadia, Omran Manar, Ghanem Hala, Elahdal Mahmoud, Kamel Nashwa, Attia Elbatoul
Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Radiation Biology Department, National Centre for Radiation Research & Technology (NCRRT), Atomic Energy Authority, Nasr City, Cairo, Egypt.
Photochem Photobiol. 2015 Jul-Aug;91(4):942-51. doi: 10.1111/php.12465. Epub 2015 Jun 4.
One inescapable feature of life on the earth is exposure to ionizing radiation. The thyroid gland is one of the most sensitive organs to gamma-radiation and endocrine disrupters. Low-level laser therapy (LLLT) has been used to stimulate tissue repair, and reduce inflammation. The aim of this study was to gauge the value of using Helium-Neon laser to repair the damaged tissues of thyroid gland after gamma-irradiation. Albino rats were used in this study (144 rats), divided into control, gamma, laser, and gamma plus laser-irradiated groups, each group was divided into six subgroups according to time of treatment (total six sessions). Rats were irradiated once with gamma radiation (6 Gy), and an external dose of laser (Wavelength 632.8 nm, 12 mW, CW, Illuminated area 5.73 cm(2), 2.1 mW cm(-2) 120 s, 1.4 J, 0.252 J cm(-2)) twice weekly localized on thyroid region of the neck, for a total of six sessions. Animals were sacrificed after each session. Analysis included thyroid function, oxidative stress markers, liver function and blood picture. Results revealed improvement in thyroid function, liver function and antioxidant levels, and the blood cells count after LLLT.
地球上生命的一个不可避免的特征是暴露于电离辐射。甲状腺是对伽马辐射和内分泌干扰物最敏感的器官之一。低强度激光疗法（LLLT）已被用于刺激组织修复和减轻炎症。本研究的目的是评估使用氦氖激光修复伽马辐射后甲状腺受损组织的价值。本研究使用了白化大鼠（144只大鼠），分为对照组、伽马辐射组、激光照射组和伽马辐射加激光照射组，每组根据治疗时间分为六个亚组（共六个疗程）。大鼠接受一次伽马辐射（6 Gy），并每周两次在颈部甲状腺区域局部照射外部激光剂量（波长632.8 nm，12 mW，连续波，照射面积5.73 cm²，2.1 mW/cm²，120秒，1.4 J，0.252 J/cm²），共六个疗程。每个疗程后处死动物。分析包括甲状腺功能、氧化应激标志物、肝功能和血常规。结果显示，低强度激光疗法后甲状腺功能、肝功能和抗氧化水平以及血细胞计数均有所改善。
