A2b 腺苷受体在心血管疾病和代谢性疾病中的多面性
The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases.
作者信息
Eisenstein Anna, Patterson Shenia, Ravid Katya
机构信息
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts.
出版信息
J Cell Physiol. 2015 Dec;230(12):2891-7. doi: 10.1002/jcp.25043.
Abstract
Modulation of the low affinity adenosine receptor subtype, the A2b adenosine receptor (A2bAR), has gained interest as a therapeutic target in various pathologic areas associated with cardiovascular disease. The actions of the A2bAR are diverse and at times conflicting depending on cell and tissue type and the timing of activation or inhibition of the receptor. The A2bAR is a promising and exciting pharmacologic target, however, a thorough understanding of A2bAR action is necessary to reach the therapeutic potential of this receptor. This review will focus on the role of the A2bAR in various cardiovascular and metabolic pathologies in which the receptor is currently being studied. We will illustrate the complexities of A2bAR signaling and highlight areas of research with potential for therapeutic development.
摘要
低亲和力腺苷受体亚型，即A2b腺苷受体（A2bAR）的调节，作为与心血管疾病相关的各种病理领域的治疗靶点已引起关注。A2bAR的作用多种多样，有时因细胞和组织类型以及受体激活或抑制的时机不同而相互矛盾。A2bAR是一个有前景且令人兴奋的药理学靶点，然而，要实现该受体的治疗潜力，有必要全面了解A2bAR的作用。本综述将聚焦于A2bAR在目前正在研究该受体的各种心血管和代谢性疾病中的作用。我们将阐述A2bAR信号传导的复杂性，并突出具有治疗开发潜力的研究领域。
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