Birdir Cahit, Janssen Katharina, Stanescu Anca Daniela, Enekwe Antje, Kasimir-Bauer Sabine, Gellhaus Alexandra, Kimmig Rainer, Köninger Angela
Department of Obstetrics and Gynecology, University Hospital of Essen, Hufelandstr. 55, 45147, Essen, Germany.
Bucur Maternity, Saint John Clinical Emergency Hospital, University of Medicine and Pharmacy, Bucharest, Romania.
Arch Gynecol Obstet. 2015 Nov;292(5):1033-42. doi: 10.1007/s00404-015-3745-7. Epub 2015 May 15.
We investigated the potential value of maternal serum copeptin, midregional proatrial natriuretic peptide (MR-proANP) and Procalcitonin (PCT) levels at 11-13 weeks' gestation in the prediction of preeclampsia (PE) in a case-control study.
Maternal serum concentration of copeptin, MR-proANP and PCT were measured at 11-13 weeks' gestation in cases of PE (n = 35) and controls (n = 100). The PE group was divided into early-onset PE (EO-PE) and late-onset PE (LO-PE). From the regression model, the value in each case and control was expressed as a multiple of the expected median (MoM). The Mann-Whitney test was used to determine the significance of differences in the median MoM in each outcome group from that in the controls.
In the PE group, compared to controls, maternal serum concentrations of copeptin, MR-proANP and PCT were not significantly different.
The maternal serum copeptin, MR-proANP and PCT levels are higher in EO-PE and LO-PE patients, but the difference is not significant. Thus, their levels in first trimester are not proven to be effective markers to screen for PE.
在一项病例对照研究中，我们调查了孕11至13周时母体血清中 copeptin、中段心房利钠肽原（MR-proANP）和降钙素原（PCT）水平在预测子痫前期（PE）方面的潜在价值。
在孕11至13周时，对35例PE患者和100例对照者的母体血清中copeptin、MR-proANP和PCT的浓度进行了测量。PE组被分为早发型PE（EO-PE）和晚发型PE（LO-PE）。从回归模型来看，每个病例和对照中的值均表示为预期中位数（MoM）的倍数。采用曼-惠特尼检验来确定每个结局组的中位数MoM与对照组相比差异的显著性。
在PE组中，与对照组相比，母体血清中copeptin、MR-proANP和PCT的浓度无显著差异。
EO-PE和LO-PE患者的母体血清copeptin、MR-proANP和PCT水平较高，但差异不显著。因此，它们在孕早期的水平未被证明是筛查PE的有效标志物。
