Department of Obstetrics and Gynecology, University Hospital of Dresden, Technical University of Dresden, Dresden, Germany.
Department of Gynecology and Obstetrics, University Hospital of Essen, Essen, Germany.
Pregnancy Hypertens. 2020 Oct;22:54-58. doi: 10.1016/j.preghy.2020.07.004. Epub 2020 Jul 13.
Midregional pro-atrial natriuretic peptide (MR-proANP) is a cardiac biomarker and the maternal serum levels could predict late-onset preeclampsia (PE) or intrauterine growth restriction (IUGR) at third trimester of pregnancy.
We measured MR-proANP between 32 and 37 weeks of pregnancy prospectively: 32 patients suffered from PE and 22 developed IUGR. 676 patients exhibited no pregnancy complications.
The median MR-proANP showed significantly higher results in PE (64.9 pmol/l (interquartile range (IQR) 36.3-105.2) and IUGR (59.7 pmol/l (IQR 39.7-163.0) groups compared to controls (38.7 pmol/l (IQR 29.7-49.2). Linear regression analysis showed association between PE and MR-proANP levels (Exp(ß) = 1.56; 95% CI: 1.34-1.81). AUC showed a predictive value for PE (AUC: 0.72) and IUGR (AUC: 0.71).
Measuring MR-proANP in maternal serum between 32 and 37 weeks of pregnancy could help predicting IUGR and PE diagnosed after 34 week in pregnancy. Thus, we assume that MR-proANP may be an additional biomarker which mirrors the maternal cardiosvascular status next to sFlt-1/PLGF representing the angiogenic status.
中段心房利钠肽前体（MR-proANP）是一种心脏生物标志物，其母血清水平可预测妊娠晚期子痫前期（PE）或胎儿生长受限（IUGR）。
我们前瞻性地测量了 32-37 周妊娠的 MR-proANP：32 例患者患有 PE，22 例发生 IUGR。676 例患者无妊娠并发症。
PE（64.9 pmol/l（IQR 36.3-105.2）和 IUGR（59.7 pmol/l（IQR 39.7-163.0）组的中位数 MR-proANP 明显高于对照组（38.7 pmol/l（IQR 29.7-49.2）。线性回归分析显示 PE 与 MR-proANP 水平之间存在相关性（Exp(ß)=1.56；95%CI：1.34-1.81）。AUC 显示对 PE（AUC：0.72）和 IUGR（AUC：0.71）具有预测价值。
在妊娠 32-37 周时测量母血清中的 MR-proANP 可帮助预测妊娠 34 周后诊断的 IUGR 和 PE。因此，我们假设 MR-proANP 可能是一种额外的生物标志物，除了代表血管生成状态的 sFlt-1/PLGF 外，还反映了母体心血管状态。
