Sasaki E, Takano H, Taenaka Y, Noda H, Tatsumi E, Kinoshita M, Sekii H, Yagura A, Akutsu T
National Cardiovascular Center, Research Institute, Suita, Osaka, Japan.
ASAIO Trans. 1989 Jul-Sep;35(3):609-11. doi: 10.1097/00002480-198907000-00143.
A simplified cannulation system was developed without thoracotomy for a ventricular assist system (VAS) that will be applicable even in an emergency. This system consists of an air driven and diaphragm type pump, cannulae, and devices for insertion. The inlet cannula was inserted into the left atrium through the femoral vein using a modified brockenbrough transseptal method. This system was installed without thoracotomy in a chronic experiment in two goats and was removed without any trouble after 14 days of pumping. In a 40 day experiment with this system implanted between the left atrium and the aorta, bypass flow was maintained at 2.7 to 3.3 L/min, and plasma free hemoglobin levels were below 7 mg/dl. When this system was implanted between the left atrium and the aorta, and activated in an induced heart failure goat, output through the pump was 3.0 +/- 0.4 L/min, and mean aortic pressure was increased to 91.7 +/- 15.9 mmHg from 55.8 +/- 15.4 mmHg. This system takes a middle position between an IABP and VAS with thoracotomy in capability of circulatory support and convenience.
一种简化的插管系统被开发出来，用于心室辅助系统（VAS），无需开胸手术，即使在紧急情况下也适用。该系统由气动隔膜式泵、插管及插入装置组成。采用改良的布罗肯布罗经房间隔穿刺法，经股静脉将入口插管插入左心房。在两只山羊的慢性实验中，该系统未开胸安装，在泵血14天后顺利取出。在一项将该系统植入左心房和主动脉之间的40天实验中，旁路血流量维持在2.7至3.3升/分钟，血浆游离血红蛋白水平低于7毫克/分升。当该系统植入左心房和主动脉之间，并在诱导性心力衰竭山羊中激活时，泵的输出量为3.0±0.4升/分钟，平均主动脉压从55.8±15.4毫米汞柱升至91.7±15.9毫米汞柱。该系统在循环支持能力和便利性方面介于主动脉内球囊反搏（IABP）和开胸心室辅助系统之间。
