Mullen Lisa M, Chamberlain Giselle, Sacre Sandra
Brighton and Sussex Medical School, Falmer, Brighton, BN1 9RY, UK.
Arthritis Res Ther. 2015 May 15;17(1):122. doi: 10.1186/s13075-015-0645-y.
The pattern recognition receptors of the innate immune system are part of the first line of defence against pathogens. However, they also have the ability to respond to danger signals that are frequently elevated during tissue damage and at sites of inflammation. Inadvertent activation of pattern recognition receptors has been proposed to contribute to the pathogenesis of many conditions including inflammatory rheumatic diseases. Prolonged inflammation most often results in pain and damage to tissues. In particular, the Toll-like receptors and nucleotide-binding oligomerisation domain-like receptors that form inflammasomes have been postulated as key contributors to the inflammation observed in rheumatoid arthritis, osteoarthritis, gout and systemic lupus erythematosus. As such, there is increasing interest in targeting these receptors for therapeutic treatment in the clinic. Here the role of pattern recognition receptors in the pathogenesis of these diseases is discussed, with an update on the development of interventions to modulate the activity of these potential therapeutic targets.
先天性免疫系统的模式识别受体是抵御病原体的第一道防线的一部分。然而，它们也有能力对在组织损伤和炎症部位经常升高的危险信号作出反应。有人提出，模式识别受体的意外激活会导致包括炎性风湿性疾病在内的许多病症的发病机制。长期炎症最常导致疼痛和组织损伤。特别是，形成炎性小体的Toll样受体和核苷酸结合寡聚化结构域样受体被认为是类风湿性关节炎、骨关节炎、痛风和系统性红斑狼疮中观察到的炎症的关键促成因素。因此，临床上针对这些受体进行治疗的兴趣日益增加。本文讨论了模式识别受体在这些疾病发病机制中的作用，并更新了调节这些潜在治疗靶点活性的干预措施的进展。
