Eördögh Réka, Schwendenwein Ilse, Tichy Alexander, Loncaric Igor, Nell Barbara
Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria.
Department for Pathobiology, Clinical Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.
Vet Ophthalmol. 2016 Jul;19 Suppl 1:4-12. doi: 10.1111/vop.12279. Epub 2015 May 15.
To describe the effects of long-term treatment with four different eye ointment bases (OBs) in cats.
Ten healthy cats.
The study was performed in two periods. Four different OBs were tested. Hundred grams of OB contained the following: OB-A: 35.17 g liquid paraffin (lp), 64.83 g white petrolatum (wp); OB-B: 10.03 g lp, 84.95 g wp 5.02 g lanolin; OB-C: 18.34 g lp, 51.40 g wp, 25.00 mg KH2 PO4 , 57.00 mg K2 HPO4 , 18.90 g eucerinum anhydricum, 11.28 g water for injections; and OB-D: 70 g unguentum lanalcoli, 20 g lp, 10 g aqua conservans. One eye was treated, and the other served as a negative control. Cats received the OBs TID for 28 days. The two study periods were separated by a 4-month washout phase. Samples for conjunctival impression cytology, swabs for bacteriologic and mycologic examination, and cytobrush samples for FHV-1 and Chlamydophila felis PCR detection were obtained. Both eyes were examined daily. Severity of ocular symptoms was scored using a modified Draize eye irritation test. A total of five eyes were treated with OB-A, five with OB-B, four with OB-C, and five with OB-D.
Treated eyes had significantly higher clinical scores. Eyes receiving OB-A had the highest overall clinical score. The results of bacteriologic and mycologic examination concur with the previously published data. All samples tested were negative for FHV-1 and Chlamydophila felis. There was no significant difference between treated and control eyes upon cytological examination.
The application of OBs resulted in clinical symptoms in treated eyes. The long-term use of ointments is not well tolerated in cats and may lead to ocular irritation.
描述四种不同眼膏基质（OBs）对猫的长期治疗效果。
10只健康猫。
研究分两个阶段进行。测试了四种不同的OBs。100克OB包含以下成分：OB - A：35.17克液体石蜡（lp），64.83克白凡士林（wp）；OB - B：10.03克lp，84.95克wp，5.02克羊毛脂；OB - C：18.34克lp，51.40克wp，25.00毫克磷酸二氢钾（KH₂PO₄），57.00毫克磷酸氢二钾（K₂HPO₄），18.90克无水优色林，11.28克注射用水；OB - D：70克羊毛脂软膏，20克lp，10克防腐剂。一只眼睛接受治疗，另一只作为阴性对照。猫每天接受三次OBs治疗，持续28天。两个研究阶段之间有4个月的洗脱期。采集结膜印片细胞学样本、用于细菌学和真菌学检查的拭子以及用于猫疱疹病毒1型（FHV - 1）和猫衣原体PCR检测的细胞刷样本。每天检查双眼。使用改良的Draize眼刺激试验对眼部症状的严重程度进行评分。共有五只眼睛用OB - A治疗，五只用OB - B治疗，四只用OB - C治疗，五只用OB - D治疗。
治疗眼的临床评分显著更高。接受OB - A治疗的眼睛总体临床评分最高。细菌学和真菌学检查结果与先前发表的数据一致。所有测试样本的FHV - 1和猫衣原体检测均为阴性。细胞学检查显示治疗眼和对照眼之间无显著差异。
应用OBs导致治疗眼出现临床症状。猫对眼膏的长期使用耐受性不佳，可能会导致眼部刺激。
