Rodriguez Ramon M, Lopez-Larrea Carlos, Suarez-Alvarez Beatriz
Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain; Fundación Renal Iñigo Álvarez de Toledo, Madrid, Spain.
Int J Biochem Cell Biol. 2015 Oct;67:75-85. doi: 10.1016/j.biocel.2015.04.020. Epub 2015 May 11.
T cell lymphopoiesis is a complex, stepwise process in which the transcriptional program of the progenitor cells is progressively adapted in order to generate mature phenotypes. This transcriptional program in differentiated cells is also very flexible, allowing the silencing or activation of critical genes in response to extrinsic or intrinsic stimuli, or, in the case of progenitors, to developmental signals. Thus, progenitor and mature cells must maintain a balance between stability, to preserve their phenotypic identity, and plasticity, to respond and adapt to stimuli. A long-standing question is, therefore, how the transcriptional program is regulated to allow both controlled differentiation and a flexible response. Here we review the contribution of epigenetic mechanisms to transcriptional control during CD4(+) T cell differentiation and the ways in which these mechanisms interact with key transcription factors to ensure proper maturation and maintenance of cell identity. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.
T细胞淋巴细胞生成是一个复杂的、逐步进行的过程，在此过程中祖细胞的转录程序会逐步调整，以产生成熟的表型。分化细胞中的这种转录程序也非常灵活，能够响应外在或内在刺激，或在祖细胞的情况下响应发育信号，使关键基因沉默或激活。因此，祖细胞和成熟细胞必须在稳定性（以保持其表型特征）和可塑性（以响应和适应刺激）之间保持平衡。因此，一个长期存在的问题是，转录程序是如何被调控以实现可控分化和灵活反应的。在这里，我们综述了表观遗传机制在CD4(+) T细胞分化过程中对转录控制的贡献，以及这些机制与关键转录因子相互作用以确保细胞身份的正确成熟和维持的方式。本文是名为：发育和疾病中的表观遗传学动态的定向问题的一部分。
