Department of Human Genetics, Leiden University Medical Centre (LUMC), 2300 RC Leiden, The Netherlands.
Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Cells. 2021 Apr 30;10(5):1074. doi: 10.3390/cells10051074.
Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphocytes. Lineage-specific transcription factors are key drivers of T cell specification and act in conjunction with epigenetic regulators that have also been elucidated as crucial players in the establishment of regulatory networks necessary for proper T cell development. In this review, we summarize the activity of transcription factors and epigenetic regulators that together orchestrate the intricacies of early T cell development with a focus on regulation of T cell lineage commitment.
造血多能祖细胞定植于胸腺，然后经历连续的发育阶段，直至成熟 T 细胞的形成。在此过程中，T 细胞的表型变化需要特定于阶段的转录程序，这些程序是向成熟淋巴细胞动态进展的基础。谱系特异性转录因子是 T 细胞特化的关键驱动因素，它们与表观遗传调节剂协同作用，这些调节剂也被阐明为建立适当 T 细胞发育所需的调控网络的关键因素。在这篇综述中，我们总结了转录因子和表观遗传调节剂的活性，它们共同协调早期 T 细胞发育的复杂性，重点是 T 细胞谱系决定的调控。
