Švagždienė Milda, Širvinskas Edmundas, Baranauskienė Dalė, Adukauskienė Dalia
Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Cardiothoracic and Vascular Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Cardiothoracic and Vascular Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Medicina (Kaunas). 2015;51(2):100-6. doi: 10.1016/j.medici.2015.03.003. Epub 2015 Apr 1.
Cardiac surgery is associated with systemic inflammatory response, which is triggered by cardiopulmonary bypass (CPB) and possibly with underlying magnesium deficiency. Animal studies have shown that magnesium deficiency intensifies oxidative stress and inflammatory processes. We aimed to find a link between serum, erythrocyte, cardiac tissue magnesium concentration and C-reactive protein (CRP) as an inflammatory marker in patients undergoing elective cardiac surgery with CPB.
The data of 27 patients undergoing elective cardiac surgery with CPB for ischemic heart disease were analyzed. Measurements were taken at the baseline, i.e., 24 h before surgery (serum magnesium, CRP); time point 1, before CPB (serum, erythrocyte and cardiac tissue magnesium); time point 2, after CPB (serum, erythrocyte and cardiac tissue magnesium), and time point 3, 15-17 h after surgery (serum, erythrocyte magnesium, CRP).
There was a negative correlation between baseline serum magnesium and baseline CRP (P=0.009; r=-0.492), negative correlation between cardiac tissue magnesium at the time point 1 and baseline CRP (P=0.021; r=-0.443), and positive correlation between CRP at time point 3 and erythrocyte magnesium at time point 2 (P<0.001; r=0.637).
The data of our study verify that inflammatory marker CRP and magnesium concentration in serum and cardiac tissue before the surgery are inversely related in patients undergoing elective cardiac surgery with CPB. Well-planned further studies are needed to evaluate the importance of underlying magnesium deficiency on the severity of systemic inflammatory response and postoperative complications after surgery with CPB.
心脏手术与全身炎症反应相关，这种反应由体外循环（CPB）引发，也可能与潜在的镁缺乏有关。动物研究表明，镁缺乏会加剧氧化应激和炎症过程。我们旨在探寻接受择期CPB心脏手术患者的血清、红细胞、心脏组织镁浓度与作为炎症标志物的C反应蛋白（CRP）之间的联系。
分析了27例因缺血性心脏病接受择期CPB心脏手术患者的数据。在基线期（即术前24小时）测量血清镁、CRP；在时间点1（CPB前）测量血清、红细胞和心脏组织镁；在时间点2（CPB后）测量血清、红细胞和心脏组织镁；在时间点3（术后15 - 17小时）测量血清、红细胞镁、CRP。
基线血清镁与基线CRP之间呈负相关（P = 0.009；r = -0.492），时间点1时的心脏组织镁与基线CRP之间呈负相关（P = 0.021；r = -0.443），时间点3时的CRP与时间点2时的红细胞镁之间呈正相关（P < 0.001；r = 0.637）。
我们的研究数据证实，接受择期CPB心脏手术的患者术前血清和心脏组织中的炎症标志物CRP与镁浓度呈负相关。需要进一步精心设计研究，以评估潜在镁缺乏对全身炎症反应严重程度及CPB术后并发症的重要性。
