Drenckhahn Christoph, Koch Stefan P, Dümmler Johannes, Kohl-Bareis Matthias, Steinbrink Jens, Dreier Jens P
Center for Stroke Research Berlin, Charité University Medicine Berlin, Berlin, Germany; Department of Neurology, Charité University Medicine Berlin, Berlin, Germany; Berlin Neuroimaging Center, Charité University Medicine Berlin, Berlin, Germany.
Berlin Neuroimaging Center, Charité University Medicine Berlin, Berlin, Germany.
Epilepsy Behav. 2015 Aug;49:118-25. doi: 10.1016/j.yebeh.2015.04.006. Epub 2015 May 11.
The electroencephalographically measured Bereitschafts (readiness)-potential in the supplementary motor area (SMA) serves as a signature of the preparation of motor activity. Using a multichannel, noninvasive near-infrared spectroscopy (NIRS) imager, we studied the vascular correlate of the readiness potential. Sixteen healthy subjects performed a self-paced or externally triggered motor task in a single or repetitive pattern, while NIRS simultaneously recorded the task-related responses of deoxygenated hemoglobin (HbR) in the primary motor area (M1) and the SMA. Right-hand movements in the repetitive sequence trial elicited a significantly greater HbR response in both the SMA and the left M1 compared to left-hand movements. During the single sequence condition, the HbR response in the SMA, but not in the M1, was significantly greater for self-paced than for externally cued movements. Nonetheless, an unequivocal temporal delay was not found between the SMA and M1. Near-infrared spectroscopy is a promising, noninvasive bedside tool for the neuromonitoring of epileptic seizures or cortical spreading depolarizations (CSDs) in patients with epilepsy, stroke, or brain trauma because these pathological events are associated with typical spatial and temporal changes in HbR. Propagation is a characteristic feature of these events which importantly supports their identification and characterization in invasive recordings. Unfortunately, the present noninvasive study failed to show a temporal delay during self-paced movements between the SMA and M1 as a vascular correlate of the readiness potential. Although this result does not exclude, in principle, the possibility that scalp-NIRS can detect a temporal delay between different regions during epileptic seizures or CSDs, it strongly suggests that further technological development of NIRS should focus on both improved spatial and temporal resolution. This article is part of a Special Issue entitled Status Epilepticus.
通过脑电图测量的辅助运动区（SMA） Bereitschafts（准备）电位是运动活动准备的标志。我们使用多通道非侵入性近红外光谱（NIRS）成像仪，研究了准备电位的血管相关性。16名健康受试者以单次或重复模式执行自定节奏或外部触发的运动任务，同时NIRS同步记录初级运动区（M1）和SMA中脱氧血红蛋白（HbR）的任务相关反应。与左手运动相比，重复序列试验中的右手运动在SMA和左M1中均引发了显著更大的HbR反应。在单序列条件下，SMA中HbR反应在自定节奏运动时显著大于外部提示运动时，而M1中则不然。尽管如此，在SMA和M1之间未发现明确的时间延迟。近红外光谱是一种有前景的非侵入性床边工具，可用于癫痫、中风或脑外伤患者癫痫发作或皮质扩散性去极化（CSD）的神经监测，因为这些病理事件与HbR典型的时空变化相关。传播是这些事件的一个特征，这对在侵入性记录中识别和表征它们非常重要。不幸的是，目前的非侵入性研究未能显示出自定节奏运动期间SMA和M1之间作为准备电位血管相关性的时间延迟。虽然这一结果原则上不排除头皮NIRS在癫痫发作或CSD期间能够检测不同区域之间时间延迟的可能性，但它强烈表明NIRS的进一步技术发展应聚焦于提高空间和时间分辨率。本文是名为“癫痫持续状态”的特刊的一部分。
