Daniel Andy G S, Laffont Philippe, Zhao Mingrui, Ma Hongtao, Schwartz Theodore H
Weill Cornell Medical College, New York Presbyterian Hospital, Department of Neurological Surgery, Brain and Mind Research Institute, Brain and Spine Center, 1300 York Avenue, Box 99, New York, NY 10021, USA.
Weill Cornell Medical College, New York Presbyterian Hospital, Department of Neurological Surgery, Brain and Mind Research Institute, Brain and Spine Center, 1300 York Avenue, Box 99, New York, NY 10021, USA; The Browning School, 52 E 62nd St, New York, NY 10065, USA.
Epilepsy Behav. 2015 Aug;49:61-5. doi: 10.1016/j.yebeh.2015.04.036. Epub 2015 May 11.
The role of glia in epilepsy has been widely debated. Using in vivo bulk loading of calcium dyes, we imaged neuronal and glial activity in an acute pharmacologic rodent model of neocortical seizures. Optical calcium-based ECoG maps revealed that neuronal waves propagated rapidly and remained mostly confined to the seizure focus. Glial waves were triggered by ictal onset but propagated slowly in a stereotypical fashion far beyond the seizure focus. Although related at their onset, the divergence of these two phenomena during seizure evolution calls into question their interdependence and the criticality of the role of glia in seizure onset and neurovascular coupling. This article is part of a Special Issue entitled "Status Epilepticus".
神经胶质细胞在癫痫中的作用一直存在广泛争议。我们通过对钙染料进行体内大量加载，在新皮质癫痫发作的急性药理学啮齿动物模型中对神经元和神经胶质细胞的活动进行成像。基于光学钙的皮层脑电图图谱显示，神经元波快速传播，且大多局限于癫痫病灶。神经胶质细胞波由发作起始触发，但以一种刻板的方式缓慢传播至癫痫病灶之外很远的地方。尽管这两种现象在起始时相关，但在癫痫发作演变过程中它们的差异使人质疑它们的相互依赖性以及神经胶质细胞在癫痫发作起始和神经血管耦合中作用的关键性。本文是名为“癫痫持续状态”的特刊的一部分。
