miR-27a rs895819 多态性与中国人群癌症风险的关联：一项荟萃分析。
miR-27a rs895819 polymorphism and risk of cancer in Chinese population: a meta-analysis.
机构信息
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, China.
出版信息
J Evid Based Med. 2015 May;8(2):75-83. doi: 10.1111/jebm.12152.
OBJECTIVE
Previous studies have evaluated the association between miR-27a rs895819 polymorphism and cancer risk in Chinese population, but the results were inconclusive. The present meta-analysis was conducted to clarify these controversies.
METHODS
A comprehensive search was conducted to identify all relevant case-control studies of miR-27a rs895819 polymorphism and cancer risk in Chinese participants. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of any association.
RESULTS
A total of 12 case-control studies involving 2655 cases and 3106 controls were included. Overall, the results suggested that there was no significant association between miR-27a rs895819 polymorphism and cancer risk in Chinese population (OR = 1.14, 95%CI 0.86 to1.15, P = 0.85 for GG vs. AA). In the subgroup analysis by the source of controls, no significant association was found either among hospital-based group (OR = 1.16, 95%CI 0.78 to 1.73) or population-based group (OR = 1.06, 95%CI 0.74 to 1.35). However, when stratified by cancer types, we found a significant association between the polymorphism with colorectal cancer (OR = 1.56, 95%CI 1.01 to 2.40 for GG vs. AA).
CONCLUSION
miR-27a rs895819 polymorphism was associated with increased risk of colorectal cancer in Chinese population.
目的
先前的研究已经评估了 miR-27a rs895819 多态性与中国人群癌症风险之间的关联，但结果尚无定论。本荟萃分析旨在澄清这些争议。
方法
进行了全面的搜索，以确定所有关于 miR-27a rs895819 多态性与中国参与者癌症风险的病例对照研究。我们计算了比值比（OR）及其 95%置信区间（CI），以评估任何关联的强度。
结果
共纳入了 12 项病例对照研究，共涉及 2655 例病例和 3106 例对照。总体而言，结果表明 miR-27a rs895819 多态性与中国人群的癌症风险之间没有显著关联（OR = 1.14，95%CI 0.86 至 1.15，P = 0.85，GG 与 AA 相比）。在按对照来源进行的亚组分析中，无论是在基于医院的组（OR = 1.16，95%CI 0.78 至 1.73）还是基于人群的组（OR = 1.06，95%CI 0.74 至 1.35）中，都没有发现显著关联。然而，当按癌症类型分层时，我们发现该多态性与结直肠癌之间存在显著关联（OR = 1.56，95%CI 1.01 至 2.40，GG 与 AA 相比）。
结论
miR-27a rs895819 多态性与中国人群结直肠癌风险增加相关。
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