Valcz Gabor, Sipos Ferenc, Tulassay Zsolt, Molnar Bela, Yagi Yukako
Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Postgrad Med J. 2015 May;91(1075):1026-31. doi: 10.1136/postgradmedj-2014-202561rep.
Carcinoma-associated fibroblast (CAF) as prominent cell type of the tumour microenvironment has complex interaction with both the cancer cells and other non-neoplastic surrounding cells. The CAF-derived regulators and extracellular matrix proteins can support cancer progression by providing a protective microenvironment for the cancer cells via reduction of chemotherapy sensitivity. On the other hand, these proteins may act as powerful prognostic markers as well as potential targets of anticancer therapy. In this review, we summarise the clinical importance of the major CAF-derived signals influencing tumour behaviour and determining the outcome of chemotherapy.
癌相关成纤维细胞（CAF）作为肿瘤微环境中突出的细胞类型，与癌细胞及其他非肿瘤性周围细胞有着复杂的相互作用。CAF衍生的调节因子和细胞外基质蛋白可通过降低化疗敏感性为癌细胞提供保护性微环境，从而支持癌症进展。另一方面，这些蛋白可能作为强大的预后标志物以及抗癌治疗的潜在靶点。在本综述中，我们总结了影响肿瘤行为并决定化疗结果的主要CAF衍生信号的临床重要性。
