Park Minyoung, Han Seung-Su, Lee Eun-Ju, Byon Mina, Kim Mi-Young, Kim Mi-Kyung, Kim Gwang Jun
Departments of Obstetrics and Gynecology.
Pathology, Chung-Ang University College of Medicine, Seoul, Korea.
J Obstet Gynaecol Res. 2015 Aug;41(8):1291-4. doi: 10.1111/jog.12715. Epub 2015 May 15.
A 31-year-old multigravida woman at 27 weeks' gestation was admitted with vaginal bleeding and a hypervascular mass near the cervix on ultrasonography. After discharge with improvement, she was readmitted the next day for uncontrolled, heavy vaginal bleeding and underwent emergency cesarean section at 29 weeks' gestation. A 3-cm friable mass found near the cervix was removed surgically; this lesion was shown to be primary cervical choriocarcinoma. On the 17th postoperative day the patient underwent total abdominal hysterectomy with preservation of both ovaries and biopsy was performed on the right ovary. The International Federation of Gynecology and Obstetrics (FIGO) stage was I and her World Health Organization prognostic score was 9, representing high risk. The patient received three rounds of chemotherapy until achieving three consecutive normal human chorionic gonadotropin levels with two additional courses to address risk of relapse. DNA genotyping on short tandem repeat polymorphism confirmed the gestational choriocarcinoma.
一名31岁的经产妇，孕27周，因阴道出血入院，超声检查发现宫颈旁有一高血管性肿块。病情好转出院后，次日因阴道出血无法控制且量多再次入院，于孕29周行急诊剖宫产。术中在宫颈旁发现一个3厘米易碎肿块并手术切除；该病变为原发性宫颈绒毛膜癌。术后第17天，患者接受了保留双侧卵巢的全腹子宫切除术，并对右侧卵巢进行了活检。国际妇产科联盟（FIGO）分期为I期，其世界卫生组织预后评分为9分，提示高风险。患者接受了三轮化疗，直至连续三次人绒毛膜促性腺激素水平正常，又追加两个疗程以降低复发风险。短串联重复多态性的DNA基因分型证实为妊娠性绒毛膜癌。
