Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK
Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK.
Eur Respir J. 2015 Sep;46(3):795-806. doi: 10.1183/09031936.00185114. Epub 2015 May 14.
As idiopathic pulmonary fibrosis emerges as an important public health problem, there is a need to coordinate data on incidence and mortality globally. This study aims to systematically assess all available studies to investigate the global burden of disease.Medline and Embase databases were searched systematically for all population-based studies of incidence or mortality of idiopathic pulmonary fibrosis. Clinical case series and prevalence studies were excluded. The search was supplemented using the Google search engine, hand-searching of references and conference abstracts. Data were extracted independently by two authors using a pre-specified proforma, with assessment of methodological quality.34 studies were identified, providing data from 21 countries from 1968-2012. 28 studies reported incidence data and eight reported mortality data. In studies from the year 2000 onwards, we estimated a conservative incidence range of 3-9 cases per 100 000 per year for Europe and North America. Incidence was lower in East Asia and South America. The majority of studies showed an increase in incidence over time.The incidence of idiopathic pulmonary fibrosis is increasing worldwide and rates are coming together across countries. Current data suggest incidence is similar to that of conditions such as stomach, liver, testicular and cervical cancers.
特发性肺纤维化作为一个重要的公共卫生问题出现，因此有必要在全球范围内协调发病率和死亡率的数据。本研究旨在系统评估所有现有的研究，以调查全球疾病负担。系统地检索了 Medline 和 Embase 数据库中所有基于人群的特发性肺纤维化发病率或死亡率的研究。排除了临床病例系列和流行率研究。使用 Google 搜索引擎、参考文献和会议摘要的手工搜索对搜索进行了补充。两位作者使用预先指定的方案独立提取数据，并对方法学质量进行评估。确定了 34 项研究，提供了来自 1968 年至 2012 年的 21 个国家的数据。28 项研究报告了发病率数据，8 项研究报告了死亡率数据。在 2000 年以后的研究中，我们估计欧洲和北美的保守发病率范围为每年每 10 万人 3-9 例。东亚和南美洲的发病率较低。大多数研究表明发病率随时间增加。特发性肺纤维化的发病率在全球范围内正在增加，并且各国的发病率正在趋同。目前的数据表明，发病率与胃癌、肝癌、睾丸癌和宫颈癌等疾病的发病率相似。
