Wang Tuoyi, Li Chunyan, Liu Yang, Li Tiezhu, Zhang Jie, Sun Yonghai
College of Food and Biological Engineering, Qiqihar University, Qiqihar 161006, Heilongjiang, China.
Clinical Pathological Diagnosis Center, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China.
Food Chem. 2015 Nov 1;186:13-9. doi: 10.1016/j.foodchem.2015.02.138. Epub 2015 Mar 6.
In this study, 0.25 μg/ml aflatoxin B1 was used to establish a liver cancer model for assessing the potential anticancer ability of Chinese cabbage powder, which is a complex water-soluble extract from Chinese cabbage by spray-drying at an outlet temperature of 130 °C. We found at least 11 potential anticancer substances in Chinese cabbage powder. A 90-d animal experiment demonstrated that 10% of Chinese cabbage powder in drinking water could improve the plasma micronutrient status, inhibit the formation of aflatoxin B1-DNA adducts in liver cells, and effectively reduce the incidence of liver tumor induced by aflatoxin B1 from 6.67% to 0%. The dose effect experiment revealed that 10% may be the minimal effective dose to prevent the occurrence of early liver tumors. This study will help elucidate the basis of epidemiological observations of dietary cancer prevention in humans, as well as explore related mechanisms.
在本研究中，使用0.25μg/ml黄曲霉毒素B1建立肝癌模型，以评估大白菜粉的潜在抗癌能力。大白菜粉是通过在130℃出口温度下喷雾干燥从大白菜中提取的一种复杂的水溶性提取物。我们在大白菜粉中发现了至少11种潜在的抗癌物质。一项为期90天的动物实验表明，饮用水中添加10%的大白菜粉可改善血浆微量营养素状况，抑制肝细胞中黄曲霉毒素B1-DNA加合物的形成，并有效将黄曲霉毒素B1诱导的肝肿瘤发生率从6.67%降至0%。剂量效应实验表明，10%可能是预防早期肝肿瘤发生的最小有效剂量。本研究将有助于阐明人类饮食防癌流行病学观察的基础，并探索相关机制。
