Ohgami R S, Arber D A
Stanford University, Stanford, CA, USA.
Int J Lab Hematol. 2015 May;37 Suppl 1:122-32. doi: 10.1111/ijlh.12367.
Acute myeloid leukemia (AML) is a complex disease, for which our understanding of the role of genetic and epigenetic changes has undergone significant advancements. Newer diagnostic and prognostic classifications have increasingly incorporated such information, and novel therapies have been developed to target specific genes, processes, and pathways based on this growing understanding. Given the rapid evolution of this field, it is critical for physicians and translational researchers to have a more in-depth understanding of this evolving landscape. Here, we review both genetics and epigenetics in acute myeloid leukemia from a practical standpoint.
急性髓系白血病（AML）是一种复杂的疾病，我们对其遗传和表观遗传变化所起作用的理解已经取得了重大进展。更新的诊断和预后分类越来越多地纳入了此类信息，并且基于这种不断加深的理解，已经开发出了针对特定基因、过程和通路的新型疗法。鉴于该领域的快速发展，医生和转化研究人员更深入地了解这一不断演变的情况至关重要。在此，我们从实际应用的角度综述急性髓系白血病中的遗传学和表观遗传学。
