Yan Ji-Dong, Liu Yanrong, Zhang Zhi-Yong, Liu Guang-Yin, Xu Jin-Heng, Liu Li-Yun, Hu Yue-Ming
Department of Thoracic Surgery, Tangshan Gongren Hospital, Tangshan, China.
High-Throughput Molecular Drug Discovery Center, Tianjin Joint Academy of Biotechnology and Medicine, Tianjin, China.
Pathol Res Pract. 2015 Jul;211(7):539-43. doi: 10.1016/j.prp.2015.04.003. Epub 2015 Apr 17.
Breast cancer is one of the most common cancers among women in the world. Vascular endothelial growth factor receptor 2 (VEGFR-2) was not only found to play a key role in the development of tumor angiogenesis, but has also been located in tumor cells of a variety of tumors. This study investigated the expression pattern of VEGFR-2 in breast cancer tissue specimens in order to evaluate the role of VEGFR-2 in the prognosis of breast cancer. Expression and localization of VEGFR-2 in tumor cells of breast cancer specimens from 98 invasive breast cancer patients were determined by immunohistochemistry. The relationships between VEGFR-2 expression and clinicopathological features were also analyzed. The results showed that VEGFR-2 expression correlated positively with lymph node (LN) metastasis of breast cancer. Patients with high expression of VEGFR-2 had a significantly worse OS. It was also observed that the expression of epithelial-mesenchymal transition (EMT) marker, including Twist1 and Vimentin, was higher in the tumors with higher VEGFR-2 expression, while the E-cadherin expression was lower in the same tumors, suggesting that VEGFR-2 may serve as a possible mediator of EMT in breast cancer.
乳腺癌是全球女性中最常见的癌症之一。血管内皮生长因子受体2（VEGFR-2）不仅在肿瘤血管生成的发展中起关键作用，还存在于多种肿瘤的肿瘤细胞中。本研究调查了VEGFR-2在乳腺癌组织标本中的表达模式，以评估VEGFR-2在乳腺癌预后中的作用。通过免疫组织化学确定了98例浸润性乳腺癌患者的乳腺癌标本肿瘤细胞中VEGFR-2的表达和定位。还分析了VEGFR-2表达与临床病理特征之间的关系。结果表明，VEGFR-2表达与乳腺癌的淋巴结（LN）转移呈正相关。VEGFR-2高表达的患者总生存期明显更差。还观察到，在VEGFR-2表达较高的肿瘤中，包括Twist1和波形蛋白在内的上皮-间质转化（EMT）标志物的表达较高，而在同一肿瘤中E-钙黏蛋白的表达较低，这表明VEGFR-2可能是乳腺癌中EMT的一个潜在介导因子。
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